Pyloric gland metaplasia and pouchitis in patients with ileal pouch-anal anastomoses

Alimentary Pharmacology & Therapeutics
R KarivBo Shen

Abstract

Diagnosis and management of chronic antibiotic-refractory pouchitis and Crohn's disease of the pouch can be challenging. Pyloric gland metaplasia is a histological feature indicative of chronic mucosal inflammation. Its value in diagnosis and prognosis of pouch disorders has not been investigated. To assess the prevalence, diagnostic and prognostic value, and risk factors of pyloric gland metaplasia in pouch patients. Patients were identified from our prospectively maintained Pouchitis Database. Pouch biopsy specimens were re-reviewed for pyloric gland metaplasia and other histological features. Two cohorts of patients were studied: a historical cohort (n = 111) and the second, a validation cohort (n = 100). Univariate and multivariate analyses were performed to assess risk factors for pyloric gland metaplasia. The prevalence of pyloric gland metaplasia in the historical cohort and validation cohort was 45 (40.1%) and 24 (24.0%), respectively. The sensitivity and specificity of pyloric gland metaplasia for the diagnosis of chronic antibiotic-refractory pouchitis or Crohn's disease were 70.7% and 92.5%, respectively, for the first cohort and 39.0% and 86.4%, respectively, for the 2nd validation cohort. In multivariate analysis o...Continue Reading

Citations

Feb 4, 2014·Virchows Archiv : an International Journal of Pathology·Cord LangnerUNKNOWN European Crohn's and Colitis Foundation
Jul 23, 2013·Journal of Crohn's & Colitis·F MagroUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Apr 2, 2013·Digestive Diseases and Sciences·Shuchi AgarwalFrancis A Farraye
Aug 9, 2013·Digestive Diseases and Sciences·Christopher R Weber, David T Rubin
Feb 24, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Annamaria PronioMonica Boirivant
Apr 23, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Bo Shen
Nov 28, 2012·The Surgical Clinics of North America·Todd D Francone, Brad Champagne
Apr 30, 2016·Archives of Pathology & Laboratory Medicine·Hwajeong LeeXiuli Liu
Aug 14, 2015·World Journal of Gastroenterology : WJG·Petros Zezos, Fred Saibil

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