Pyloric gland type adenoma of the gallbladder with squamoid spindle cell metaplasia

Pathology, Research and Practice
R KushimaF Borchard

Abstract

This study documents a pyloric gland type adenoma of the gallbladder with prominent spindle cell metaplasia arising in a 61 year-old woman. A pedunculated polyp, 1.5 x 1.0 x 1.0 cm, was histologically diagnosed as a tubular adenoma. Most glandular structures showed positivity for a monoclonal antibody M2 (2B5) which indicates a differentiation to pylotic gland type. The spindle cell component displayed no apparent epithelial structures but stained mostly positive for pancytokeratin and cytokeratin (CK) 18, and focally for CK 5 + 6, CKs 7 and 19, whereas CKs 8, 13, 20, and non-epithelial markers could not be demonstrated. This suggests that the spindle cells were immature epithelial cells differentiating towards squamous and/or glandular cells. Even in spindle cell areas, the nuclear atypia was mild, and proliferating cells positive for MIB-1 (Ki-67) antigen were infrequently seen. This unique phenomenon, of which only three cases have been previously reported, is considered to represent benign squamoid spindle cell metaplasia.

Citations

Apr 20, 2005·Virchows Archiv : an International Journal of Pathology·Ryoji KushimaManfred Stolte
Sep 5, 2006·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Ryoji KushimaTakanori Hattori
Oct 3, 2008·The American Journal of Surgical Pathology·Zong-Ming ChenElizabeth Montgomery
Apr 20, 2005·Virchows Archiv : an International Journal of Pathology·M ViethM Stolte
Oct 11, 2011·Annales de pathologie·Denis Chatelain, Jean-François Fléjou
Jun 2, 2015·Archives of Pathology & Laboratory Medicine·Maryam Kherad Pezhouh, Jason Y Park
Aug 6, 2014·Journal of Clinical Pathology·Michael Vieth, Elizabeth Anne Montgomery
Dec 27, 2017·Histopathology·Won-Tak ChoiGregory Y Lauwers
Sep 10, 2010·Virchows Archiv : an International Journal of Pathology·Michael ViethTakanori Hattori
Apr 26, 2003·Virchows Archiv : an International Journal of Pathology·M ViethM Stolte
Jan 1, 2021·Histopathology·Bence KőváriGregory Y Lauwers

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