Pyoderma Gangrenosum among Patients with Inflammatory Bowel Disease: A Descriptive Cohort Study

Journal of Cutaneous Medicine and Surgery
Adam WeizmanGil Y Melmed

Abstract

Pyoderma gangrenosum (PG) is a severe extraintestinal manifestation of inflammatory bowel disease (IBD). To better characterize PG features and management among an IBD cohort. Subjects with PG were identified using a large database at a tertiary center. Patient demographics and clinical characteristics were summarized using descriptive statistics. Eighty patients with an episode(s) of PG were identified, yielding an overall prevalence of 1.9%. Overall, 93% of patients with PG had some degree of colonic inflammation. Thirty-one (39%) patients required hospitalization for PG. Underlying bowel disease was active at the time of PG episode(s) in 52 (65%) patients. The PG location was variable, with the lower extremity being the most common. Most patients (71.3%) required multiple therapies to achieve PG healing. We describe one of the largest case series of PG among patients with IBD. The variety of treatment strategies used highlights the lack of clear guidelines in managing this complex group of patients.

References

Jan 1, 1968·The British Journal of Dermatology·D I McCallum, P D Kinmont
Mar 1, 1980·Gut·J R ThorntonA E Read
Mar 1, 1996·Journal of the American Academy of Dermatology·F C PowellH O Perry
Jun 1, 1996·Journal of the American Academy of Dermatology·R K Chow, V C Ho
Feb 21, 1998·The British Journal of Dermatology·P von den Driesch
Mar 20, 2001·Zeitschrift für Gastroenterologie·A TrommT Griga
Apr 24, 2001·The American Journal of Gastroenterology·C N BernsteinN Yu
Aug 9, 2003·The American Journal of Gastroenterology·Miguel RegueiroGary R Lichtenstein
Jun 19, 2004·The Journal of Dermatological Treatment·D VidalA Alomar
Jul 16, 2005·Journal of the American Academy of Dermatology·Jörg ReichrathWolfgang Tilgen
Oct 26, 2005·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Hugh J Freeman
Nov 22, 2008·Inflammatory Bowel Diseases·Ilhami YükselNurgül Saşmaz
Feb 9, 2010·Gastroentérologie Clinique Et Biologique·F MedkourH Le-Louet
Jul 20, 2010·Clinical and Experimental Immunology·A V MarzanoC Crosti
Jul 30, 2010·The Journal of Dermatological Treatment·Angelo Valerio MarzanoCarlo Crosti
Sep 3, 2010·The American Journal of Gastroenterology·Stephan R VavrickaAlain M Schoepfer
Feb 5, 2011·Journal of the American Academy of Dermatology·Ahmed Hadi, Mark Lebwohl
Aug 13, 2011·The Australasian Journal of Dermatology·Amanda SaracinoAlvin Chong
Aug 7, 2013·Alimentary Pharmacology & Therapeutics·A Agarwal, J M Andrews

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Citations

Sep 13, 2019·International Journal of Dermatology·Monica ShahAbdulhadi Jfri
Nov 16, 2017·Advances in Skin & Wound Care·Eran ShavitR Gary Sibbald
Apr 26, 2019·Current Opinion in Gastroenterology·Erica J Brenner, Millie D Long
Jun 25, 2020·Clinical and Experimental Dermatology·V PremjeyanthK E Shipman
Feb 23, 2017·American Journal of Clinical Dermatology·Afsaneh AlaviRobert S Kirsner
Nov 5, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Steven D Billings
Sep 12, 2019·Medicina·Ludovico AbenavoliSteven Paul Nisticò
Aug 3, 2021·Journal of the Canadian Association of Gastroenterology·Parul TandonAdam V Weizman

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BETA
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