Pyoderma gangrenosum associated with solid organ malignancies

International Journal of Dermatology
Varun Shahi, David A Wetter

Abstract

Pyoderma gangrenosum (PG) can be associated with systemic diseases, including inflammatory bowel disease, inflammatory arthritis, and hematologic malignancy. Previous literature exploring the rare association between PG and solid organ malignancy is predominantly limited to single case reports. We retrospectively reviewed the cases of five patients with PG and solid organ malignancies at our institution between 1996 and 2013. For the five patients identified, PG and solid organ malignancy occurred within three months of each other. Mean age at onset of PG was 55.6 years, and four patients were women. Three patients had breast carcinoma (one was recurrent), and two had gastrointestinal carcinoma. PG occurred before (n = 2), after (n = 2), or synchronously with (n = 1) the malignancy. In one patient with a history of PG and quiescent inflammatory bowel disease, recurrent PG developed synchronously with a new diagnosis of metastatic rectosigmoid carcinoma. Three patients had partial or complete response of PG with treatment of PG alone. To our knowledge, our study is the first to report that the onset of PG can herald a recurrence of a solid organ malignancy and that recurrent PG can be associated with solid organ malignancy. A po...Continue Reading

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Citations

Oct 17, 2015·The British Journal of Dermatology·A G A KoliosL E French
Jul 26, 2015·Journal of the American Academy of Dermatology·Stanislav N TolkachjovMichael J Camilleri
Sep 13, 2019·International Journal of Dermatology·Monica ShahAbdulhadi Jfri
Sep 13, 2019·Annals of Plastic Surgery·Juan Rodolfo MellaLifei Guo
Feb 2, 2018·Annals of Dermatology·Hye Rin YouSeung-Chul Lee
Jul 6, 2020·Archives of Dermatological Research·Shanthi Narla, Jonathan I Silverberg
Dec 8, 2019·Journal of Medical Case Reports·Fousséni AlassaniKomla Attipou
Mar 21, 2020·BMJ Case Reports·Samantha Ann PellegrinoMeron Pitcher
Nov 24, 2020·International Journal of Dermatology·Emily C MilamMiriam K Pomeranz
Mar 7, 2021·International Journal of Dermatology·Rebeca CaladoLuis Santiago
Jun 3, 2021·The Australasian Journal of Dermatology·Khalaf KridinArnon D Cohen
Feb 28, 2017·Gynécologie, Obstétrique, Fertilité & Sénologie·J GobertF Sergent

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