Pyoderma gangrenosum mimicking abdominal sepsis after colorectal surgery

Journal de chirurgie
E HornezH Thouard

Abstract

This study reports a case of pyoderma gangrenosum arising at a drainage orifice after a colostomy for cancer. The initial clinical presentation suggested intra-abdominal sepsis but the clinical assessment did not fit with laboratory findings or the CT scan. Forty hours later, the patient developed a reddish-purple ulcer at the drainage orifice. A diagnosis of pyoderma gangrenosum was made and systemic corticosteroid therapy was started. A dramatic response occurred over the next two days, obviating the need for surgical re-intervention. Pyoderma gangrenosum is an ulcerating necrotizing skin disorder of unknown etiology. It usually arises in association with underlying disease (mainly inflammatory bowel disease) and often occurs in para-stomal sites. Pyoderma gangrenosum arising at surgical sites is often mistaken for a postoperative infection and treated inappropriately with debridement and reopening of the wound which only exacerbates the pathology. Pyoderma gangrenosum is effectively treated with systemic corticosteroids.

References

Jul 1, 1992·The British Journal of Dermatology·C C LongP J Holt
Mar 15, 1986·British Medical Journal·A J CarrC T Harrington
Sep 1, 1985·The Journal of Dermatologic Surgery and Oncology·R K FulbrightJ A Tschen
Sep 1, 1995·International Journal of Dermatology·P EsnaultD Leroy
Sep 23, 2000·JAMA : the Journal of the American Medical Association·A P HughesJ P Callen
Aug 10, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·M Borlu, S Utaş
Nov 1, 2002·The New England Journal of Medicine·Pareshkumar Patel, Arthur Topilow
Jan 11, 2005·La Revue de médecine interne·D Wallach
Jul 18, 2006·Journal of the American Academy of Dermatology·Mark D P DavisSteven E Prawer

❮ Previous
Next ❯

Citations

Oct 31, 2012·International Wound Journal·Ilknur AltunayGulsen Tukenmez Demirci

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Diseases of the Colon and Rectum
J J Tjandra, L E Hughes
Journal of the European Academy of Dermatology and Venereology : JEADV
E GüngörN Lenk
Annals of the Royal College of Surgeons of England
E BagouriG Geutjens
Journal of Cutaneous Medicine and Surgery
Dale A Classen, Chris Thomson
© 2022 Meta ULC. All rights reserved