Pyostomatitis vegetans and its relation to inflammatory bowel disease, pyoderma gangrenosum, pyodermatitis vegetans, and pemphigus

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
M M S NicoS V Lourenço

Abstract

Pyostomatitis vegetans (PSV) is an intraoral pustular eruption considered by most authors to represent the mucous analogous of cutaneous pyoderma gangrenosum and its vegetating presentations (pyodermatitis vegetans). A strong correlation of PSV with inflammatory bowel disease (IBD) is well documented. The histopathology of PSV lesions usually reveals acanthosis, and neutrophils and/or eosinophils infiltration with intraepithelial or subepithelial abscesses; acantholysis is present in some cases. We studied four patients with IBD that presented oral lesions suggestive of PSV. Two male and two female patients were included. The histopathology of oral lesions of two patients revealed findings typical for PSV. The other two patients showed findings typical for pemphigus vulgaris (PV), although the course of their symptoms paralleled that of the bowel disease. Our findings may suggest that pustular lesions in patients with IBD can be a presentation of both PSV and PV; adequate diagnosis is required because clinical presentation is very similar.

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Citations

Jan 1, 2014·World Journal of Gastroenterology : WJG·Kamran B LankaraniShima Hassanpour
Jan 16, 2016·Gerodontology·Ruchadaporn KaomongkolgitKobkan Thongprasom
Jul 1, 2015·The British Journal of Dermatology·M ShephardT A Hodgson
Apr 9, 2016·Indian Journal of Dermatology·Anza KhaderShyni P Manakkad
Mar 20, 2015·Clinical and Experimental Dermatology·K HeelanN H Shear
Jun 29, 2016·Journal of the American Academy of Dermatology·Leon G ClarkMichael J Camilleri
Feb 10, 2018·Intestinal research·Joo Wan SeoWoo Kyeong Kim
Jan 1, 2014·Terapevticheskiĭ arkhiv·V D El'kinE V Plotnikova

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