Abstract
Pyothorax-associated lymphoma (PAL) is a rare, but distinct, clinico-pathologic entity which occurs most often in Japanese people; to the best of our knowledge, only six cases of it have been reported in Western countries. The tumour develops several decades following artificial pneumothorax or chronic pleuritis due to tuberculous infection, produces pleural effusion associated with extensive local lymphomatous infiltrates, and is sustained by a polymorphic large B-cell clonal proliferation showing EBV integration in the genoma of the neoplastic cells. Herein we describe two cases of PAL observed in Italian patients, both extensively studied on the clinical, pathological, phenotypic, virological, and molecular levels. The two cases occurred, respectively, 45 and 50 years after therapeutic pneumothorax because of tuberculous pleuritis and were characterized by a pleural mass extending to the thoracic wall, which on histological examination were seen to consist of large elements with immunoblastic morphology. Immunohistochemistry show monotypic restriction of Ig light chains, as well as the expression of CD45, B-cell markers (CD20, CD79a, CD45RA), bcl-2 oncogene product, EBNA-2 and, partially, LMP-1. The ratio of cycling cells wa...Continue Reading
Citations
May 23, 2002·The American Journal of Surgical Pathology·Bruno PetitjeanPhilippe Gaulard
Dec 4, 2002·Histopathology·S A PileriP L Zinzani
Jan 1, 2009·Journal of Hematopathology·Leticia Quintanilla-MartinezGerman Ott
Jan 12, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Florence LoongJohn K C Chan
Jul 31, 2013·American Journal of Clinical Pathology·William WuXiaohui Zhao
Apr 24, 2014·World Journal of Surgical Oncology·Xiaoming QiuQinghua Zhou
Nov 21, 2018·Annals of Hematology·Magda ZanelliStefano Ascani
Jun 20, 2015·Journal of Surgical Case Reports·Man-Chi LauJim McGuigan
Jun 11, 2002·Current Opinion in Pulmonary Medicine·Valeria Ascoli, Francesco Lo-Coco
Jan 14, 2004·Histopathology·A AndroulakiT Dosios
Dec 5, 2008·Histopathology·Bruce Addis, Heather Roche
Feb 15, 2017·The American Journal of Surgical Pathology·Daniel F BoyerAliyah R Sohani
Nov 22, 2018·Medicine·Qianwen ZhangXiaoqin Liu
Oct 1, 2019·Advances in Anatomic Pathology·Sergio Piña-Oviedo, Cesar A Moran
Jan 25, 2019·Infectious Diseases·Erasmia RoukaSotirios G Zarogiannis
Apr 11, 2017·American Journal of Clinical Pathology·Yasodha NatkunamElaine S Jaffe
Aug 18, 1999·Journal of the Royal Society of Medicine·R Amin
Mar 10, 2018·Pathogens·Stefan D DojcinovLeticia Quintanilla-Martinez
Feb 22, 2005·Histopathology·L LeonciniH Stein
Feb 11, 2021·Journal of Oncology·Guang-Liang ChenJunning Cao
Aug 1, 2009·Archives of Pathology & Laboratory Medicine·Sandeep GurbuxaniElizabeth Hyjek
Dec 1, 2010·Surgical Pathology Clinics·Laurence de Leval