Pyothorax-associated lymphoma: development of Epstein-Barr virus-associated lymphoma within the inflammatory cavity

Pathology International
M FukayamaK Nakahiro

Abstract

Pyothorax-associated lymphoma (PAL) is a B cell lymphoma that develops in Japanese patients with tuberculosis-associated chronic pyothorax (TaCP). Epstein-Barr virus (EBV) has been shown to be causally related to PAL. To clarify the developmental process of PAL, the systemic and local presence of EBV, and serum profile of anti-EBV antibodies was investigated in TaCP. EBV genome was found in peripheral blood mononuclear cells by PCR in a 10(-4)-10(-5) amount of Raji cell-DNA in three of four patients with TaCP, but was also identified in patients with pyothorax caused by other diseases (2/2) or without pulmonary diseases (2/6). EBER1 in situ hybridization and EBNA2 immunocytochemistry revealed clusters of EBV-carrying cells in the cavity content (3/18) but not at the pyothorax wall; EBV(+) histological lymphoma cells were found in two cases and EBV(+) mononuclear cells were found in one case. A simultaneous increase in serum titers of anti-EBV viral capsid antigen IgG and IgA antibodies was observed in TaCP (4/16). These results suggest that a local factor, an inflammatory cavity, has a pivotal role in the development of PAL, which might be reflected in the serum titers of anti-EBV antibodies in patients with TaCP.

References

Jan 15, 1976·International Journal of Cancer. Journal International Du Cancer·G Henle, W Henle
Mar 1, 1992·Journal of Clinical Pathology·M M Reid
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S E PikeG Tosato
Jul 16, 1985·Biochemical and Biophysical Research Communications·S E GoelzB Vogelstein
Aug 1, 1994·Journal of Clinical Pathology·S Shousha, Y A Luqmani
Jun 1, 1994·Journal of Clinical Pathology·K HoriuchiK Aozasa
Jan 1, 1993·Japanese Journal of Cancer Research : Gann·K AozasaM Shimoyama

❮ Previous
Next ❯

Citations

Oct 20, 1998·Pathology International·H Kanno, K Aozasa
Aug 7, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jennings NestorSteven Sahn
Dec 23, 2008·Advances in Anatomic Pathology·Siok-Bian Ng, Joseph D Khoury
Oct 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shin-Ichi NakatsukaKatsuyuki Aozasa
May 12, 2017·Journal of Medical Case Reports·Weerapat OwattanapanichSanya Sukpanichnant
Oct 18, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H NarimatsuS Nakamura

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.