Pyramidal appearance and resistive index: insensitive and nonspecific sonographic indicators of renal transplant rejection

AJR. American Journal of Roentgenology
F KelczT D Oberly

Abstract

Renal transplantation patients undergoing biopsy were examined with duplex Doppler sonography to establish the sensitivity and specificity of this technique in the detection of rejection. The study population consisted of 89 consecutive patients, who received renal transplants 1 week to 17 years before our examination and underwent 96 core needle biopsies within 24 hr of sonography. The resistive index (RI), defined as the difference between the peak systolic and end diastolic flow velocities divided by the peak systolic velocity (expressed as a percentage), was measured in the main, segmental, interlobar, and arcuate renal arteries. Furthermore, the prominence of the renal pyramids, as determined by their size and echogenicity, was prospectively evaluated. Biopsy was used to establish diagnosis, but in cases of equivocal results, hospital course was the final arbiter. The most frequent diagnoses in the patients were acute rejection (41 patients) and chronic rejection (19 patients). Receiver-operating-characteristic curve analysis established that, regardless of the vessel in which it was measured, the use of RI to assign a diagnosis of acute rejection was no better than establishing this in a random manner. We did note, howeve...Continue Reading

Citations

Oct 1, 1992·Journal of Clinical Ultrasound : JCU·E Jurriaans, P A Dubbins
Sep 25, 2012·Intensive Care Medicine·David Schnell, Michael Darmon
Mar 1, 1993·Clinical Radiology·S H Lee, C G Newstead
Dec 9, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·K WollenbergB Krumme
Mar 21, 2003·AJR. American Journal of Roentgenology·Mitchell E TublinJoel F Platt
Mar 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M M FitzpatrickI Gordon
Sep 13, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jason N NixonMarguerite T Parisi
Oct 1, 1992·Journal of Clinical Ultrasound : JCU·M Pelling, P A Dubbins
Oct 1, 1992·Journal of Clinical Ultrasound : JCU·J F Griffin, M M McNicholas
Oct 1, 1992·Journal of Clinical Ultrasound : JCU·C Deane
Jun 4, 2013·Transplantation Proceedings·A A RiglerJ Buturović-Ponikvar
Mar 29, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W Charles O'neill, Deborah A Baumgarten
Oct 14, 2009·Clinical Radiology·D H KayG Baxter
Oct 23, 2003·Ultrasound Quarterly·Grant M Baxter
Mar 22, 2001·International Journal of Urology : Official Journal of the Japanese Urological Association·A KondoH Ito
Nov 3, 2006·Critical Care Medicine·Andrew W KirkpatrickSavvas Nicolaou
Aug 8, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Angelo SaracinoVito Gaudiano
Apr 28, 2019·European Radiology·Hakan İmamoğluNuri Erdoğan
Jul 8, 1999·Journal of Clinical Ultrasound : JCU·R H GottliebO L Bronsther
Jun 1, 1997·Journal of Clinical Ultrasound : JCU·D S RajM Yeung
Dec 20, 2018·Clinical Hemorheology and Microcirculation·Stephanie PreussKonrad Friedrich Stock

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