PyramidalExplorer: A New Interactive Tool to Explore Morpho-Functional Relations of Human Pyramidal Neurons

Frontiers in Neuroanatomy
Pablo TohariaRuth Benavides-Piccione

Abstract

This work presents PyramidalExplorer, a new tool to interactively explore and reveal the detailed organization of the microanatomy of pyramidal neurons with functionally related models. It consists of a set of functionalities that allow possible regional differences in the pyramidal cell architecture to be interactively discovered by combining quantitative morphological information about the structure of the cell with implemented functional models. The key contribution of this tool is the morpho-functional oriented design that allows the user to navigate within the 3D dataset, filter and perform Content-Based Retrieval operations. As a case study, we present a human pyramidal neuron with over 9000 dendritic spines in its apical and basal dendritic trees. Using PyramidalExplorer, we were able to find unexpected differential morphological attributes of dendritic spines in particular compartments of the neuron, revealing new aspects of the morpho-functional organization of the pyramidal neuron.

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Citations

Mar 28, 2019·Frontiers in Neuroanatomy·Diana FurcilaLidia Alonso-Nanclares
Jan 9, 2019·Frontiers in Neuroanatomy·Jose Juan Aliaga MaraverLuis Pastor

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Methods Mentioned

BETA
electron microscopy

Software Mentioned

Detail
Connectome Explorer
GENESIS
OpenGL
Linux
PyramidalExplorer
Windows
Neuron
Detail viewer
Neuron Navigator

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