PMID: 3214171Dec 1, 1988Paper

Pyrazole is different from acetone and ethanol as an inducer of the polysubstrate monooxygenase system in mice: evidence that pyrazole-inducible P450Coh is distinct from acetone-inducible P450ac

Archives of Biochemistry and Biophysics
P HonkakoskiM A Lang

Abstract

The induction of liver microsomal monooxygenase activities elicited by pyrazole, ethanol, and acetone, all shown to be inducers of rat P450j and rabbit P450LM3a, has been compared in inbred strains of DBA/2N, AKR/J, and Balb/c mouse. Pyrazole strongly increases coumarin 7-hydroxylase (COH) activity in DBA/2N but much less in other strains. The effect of pyrazole on aniline p-hydroxylase and ethanol oxidase activities is also strain dependent: an increase was seen only in the DBA/2N strain. Ethanol and acetone were unable to induce COH, whereas aniline p-hydroxylase and ethanol oxidase were elevated about 1.4- to 3.3-fold in all strains. No strain difference could be detected in aniline p-hydroxylase or ethanol oxidase inducibility. There was a strong correlation between aniline p-hydroxylase and ethanol oxidase activities in every strain, whereas no positive correlation could be found between COH and aniline p-hydroxylase activities. Immunoinhibition experiments showed that a polyclonal antibody against purified pyrazole-inducible COH (P450Coh) blocked about 90% of COH activity, but only about 10% of aniline p-hydroxylase or ethanol oxidase in mouse liver microsomes. Monoclonal antibody 1-91-3 (raised against rat acetone-induci...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jan 1, 1979·Pharmacology & Therapeutics·R Snyder, H Remmer
Jul 1, 1978·Analytical Biochemistry·D Dagani, M C Archer
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·P KaipainenM Lang
Jan 1, 1986·CRC Critical Reviews in Biochemistry·M Adesnik, M Atchison
Dec 1, 1986·Archives of Biochemistry and Biophysics·C J PattenC S Yang
Feb 1, 1987·DNA·D W NebertW Levin
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Jan 1, 1985·British Journal of Clinical Pharmacology·O PelkonenJ T Ahokas
Apr 30, 1985·Biochemical and Biophysical Research Communications·C S YangM J Coon
Oct 1, 1985·European Journal of Biochemistry·R O JuvonenM A Lang
Jul 15, 1982·Biochemical Pharmacology·D W Nebert, M Negishi
Nov 15, 1984·Archives of Biochemistry and Biophysics·D R KoopM J Coon
Nov 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·F P GuengerichL S Kaminsky
Nov 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D E RyanW Levin
Dec 15, 1981·Biochemical and Biophysical Research Communications·Y Y TuC S Yang

❮ Previous
Next ❯

Citations

Oct 9, 1991·Biochemical Pharmacology·A KojoM Lang
Nov 6, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yongke LuArthur I Cederbaum
Oct 21, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Elena PirasEva B Brittebo
Apr 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M M PetersB G Lake
Jun 18, 2003·Archives of Insect Biochemistry and Physiology·Danielle BrownJeffrey G Scott
Jan 22, 1992·Biochemical Pharmacology·D E Goeger, K E Anderson
Dec 1, 1989·Biochemical Pharmacology·P R SinclairJ F Sinclair

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.