Pyrene exposure influences the craniofacial cartilage development of Sebastiscus marmoratus embryos

Marine Environmental Research
Xiao ShiChonggang Wang

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants, which are known carcinogens and teratogens. However, the toxicity of PAHs during skeletal development and the mechanism involved are not completely clear. In the present study, rockfish (Sebastiscus marmoratus) embryos were exposed to pyrene (Pyr) for 7 days at 0.5, 5 and 50 nM which resulted in craniofacial skeleton deformities. Pyr exposure for 6 days reduced the expression of PCNA, Col2a1 and Sox9 in the craniofacial skeleton revealed using in situ hybridization. These results suggest that Pyr exposure impairs skeleton development via disrupting the proliferation of the chondrocytes. At the same time, Pyr exposure reduced the expression of lox1 and inhibited the activity of lysyl oxidase, which is the key enzyme controlling the collagen cross-linking, and which might therefore have been one of the reasons for the deformative Meckel's cartilage (lower jaw).

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Citations

Mar 25, 2014·Environmental Science and Pollution Research International·Caroline VignetXavier Cousin
Mar 22, 2014·Environmental Science and Pollution Research International·Caroline VignetXavier Cousin
Feb 15, 2016·Aquatic Toxicology·Vicki L MarlattChristopher J Martyniuk
Aug 14, 2012·Aquatic Toxicology·Chengyong HeChonggang Wang
Aug 4, 2016·Journal of Toxicology and Environmental Health. Part a·Bjørn Henrik HansenPål A Olsvik
Feb 12, 2021·Animals : an Open Access Journal From MDPI·Rodolfo Martín-Del-CampoAlejandra García-Gasca
Jul 10, 2019·Marine Environmental Research·Bjørn Henrik HansenElin Kjørsvik
Jun 10, 2020·Ecotoxicology and Environmental Safety·Chen TangZhenghong Zuo

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