Abstract
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants, which are known carcinogens and teratogens. However, the toxicity of PAHs during skeletal development and the mechanism involved are not completely clear. In the present study, rockfish (Sebastiscus marmoratus) embryos were exposed to pyrene (Pyr) for 7 days at 0.5, 5 and 50 nM which resulted in craniofacial skeleton deformities. Pyr exposure for 6 days reduced the expression of PCNA, Col2a1 and Sox9 in the craniofacial skeleton revealed using in situ hybridization. These results suggest that Pyr exposure impairs skeleton development via disrupting the proliferation of the chondrocytes. At the same time, Pyr exposure reduced the expression of lox1 and inhibited the activity of lysyl oxidase, which is the key enzyme controlling the collagen cross-linking, and which might therefore have been one of the reasons for the deformative Meckel's cartilage (lower jaw).
References
Sep 23, 1997·Experimental Cell Research·C YangD J Prockop
Sep 11, 1998·Atherosclerosis·A BrüelH Oxlund
Feb 22, 2001·Developmental Biology·E F ChiangB Chung
Dec 26, 2001·Nucleic Acids Research·Andreas D Baxevanis
May 9, 2002·Environmental Pollution·K MaskaouiZ L Zhang
Nov 5, 2002·Genes & Development·Haruhiko AkiyamaBenoit de Crombrugghe
Jun 28, 2003·Journal of Cell Science·Giovanni Maga, Ulrich Hubscher
Apr 15, 2004·Toxicology and Applied Pharmacology·John P IncardonaNathaniel L Scholz
Dec 24, 2004·Histochemistry and Cell Biology·Thomas KöhlerBeate Brand-Saberi
Feb 4, 2005·Development·Yi-Lin YanJohn H Postlethwait
May 25, 2005·Journal of Chromatography. a·Chimezie AnyakoraHerbert Coker
Sep 28, 2005·Birth Defects Research. Part C, Embryo Today : Reviews·Véronique Lefebvre, Patrick Smits
Sep 30, 2005·The American Journal of Pathology·Joni M MäkiJohanna Myllyharju
Dec 7, 2005·Environmental Health Perspectives·John P IncardonaNathaniel L Scholz
Jun 20, 2006·Bioresource Technology·Wen-Tien TsaiJeng-Hung Chang
Nov 23, 2006·Toxicology and Applied Pharmacology·John P IncardonaNathaniel L Scholz
Jan 12, 2007·Molecular BioSystems·Carrie AndersonJames Dowden
Jul 17, 2007·Osteoarthritis and Cartilage·A AsanbaevaR L Sah
Jul 31, 2007·The International Journal of Biochemistry & Cell Biology·E J MackieM Mirams
Aug 22, 2007·Trends in Cell Biology·L S Cox
Jun 27, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Chengyong HeZhenghong Zuo
Jan 11, 2011·Aquatic Toxicology·Chengyong HeChonggang Wang
Citations
Aug 8, 2013·Journal of Hazardous Materials·Lixing HuangZhenghong Zuo
Mar 25, 2014·Environmental Science and Pollution Research International·Caroline VignetXavier Cousin
Mar 22, 2014·Environmental Science and Pollution Research International·Caroline VignetXavier Cousin
Feb 15, 2016·Aquatic Toxicology·Vicki L MarlattChristopher J Martyniuk
Aug 14, 2012·Aquatic Toxicology·Chengyong HeChonggang Wang
May 6, 2014·Marine Pollution Bulletin·Yuki SugaharaYasunori Murakami
Aug 4, 2016·Journal of Toxicology and Environmental Health. Part a·Bjørn Henrik HansenPål A Olsvik
Jun 7, 2017·Environmental Toxicology and Chemistry·Daniel R BrownRichard T Di Giulio
Aug 2, 2020·The Science of the Total Environment·Cyril RigaudEeva-Riikka Vehniäinen
Feb 12, 2021·Animals : an Open Access Journal From MDPI·Rodolfo Martín-Del-CampoAlejandra García-Gasca
Jul 10, 2019·Marine Environmental Research·Bjørn Henrik HansenElin Kjørsvik
Jun 10, 2020·Ecotoxicology and Environmental Safety·Chen TangZhenghong Zuo