Pyrethroid resistance in Aedes aegypti from Grand Cayman

The American Journal of Tropical Medicine and Hygiene
Angela F HarrisHilary Ranson


The Grand Cayman population of Aedes aegypti is highly resistant to DDT and pyrethroid insecticides. Glutathione transferase, cytochrome P450, and esterase levels were increased in the Grand Cayman population relative to a susceptible laboratory strain, but synergist studies did not implicate elevated insecticide detoxification as a major cause of resistance. The role of target site resistance was therefore investigated. Two substitutions in the voltage-gated sodium channel were identified, V1016I in domain II, segment 6 (IIS6) (allele frequency = 0.79) and F1534C in IIIS6 (allele frequency = 0.68). The role of the F1534C mutation in conferring resistance to insecticides has not been previously established and so a tetraplex polymerase chain reaction assay was designed and used to genotype mosquitoes that had been exposed to insecticides. The F1534C mutation was strongly correlated with resistance to DDT and permethrin.


Jan 30, 1999·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·S C Rawlins
Aug 12, 1999·Biochemical and Biophysical Research Communications·H HeJ E George
Sep 18, 2002·Archives of Medical Research·Duane J Gubler
Jun 10, 2005·Insect Biochemistry and Molecular Biology·Nongkran LumjuanHilary Ranson
Feb 16, 2006·The Biochemical Journal·Andrias O O'ReillyT G Emyr Davies
Dec 12, 2007·Insect Biochemistry and Molecular Biology·Clare StrodeHilary Ranson
May 16, 2008·Pest Management Science·Anna C KhotGraham D Moores
Oct 16, 2009·PLoS Neglected Tropical Diseases·Gustavo Ponce GarcíaWilliam C Black IV
Jan 27, 2010·Journal of the American Mosquito Control Association·Andrew J MackayRoberto Barrera
Jan 1, 2008·Molecular Ecology Resources·François Rousset
Apr 7, 2017·Annual Review of Public Health·C Hendricks BrownGracelyn Cruden


Mar 1, 2011·Transactions of the Royal Society of Tropical Medicine and Hygiene·Shavanthi RajatilekaHilary Ranson
Nov 1, 2011·Nature Biotechnology·Angela F HarrisLuke Alphey
Apr 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Christopher M JonesCraig S Wilding
Apr 2, 2011·Vector Borne and Zoonotic Diseases·Ephantus J Muturi, Barry W Alto
Jan 9, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jean-Philippe DavidMark Paine
Jan 17, 2014·Parasites & Vectors·Jutta Gerlinde Birggitt LinssAdemir Jesus Martins
May 2, 2014·Parasitology Research·Sharon Smith VeraJonny E Duque Luna
Dec 3, 2014·Pesticide Biochemistry and Physiology·Ronald Maestre-SerranoAdriana E Flores
Dec 20, 2013·Environmental Science and Pollution Research International·Chandran Sundaravadivelan, Madanagopal Nalini Padmanabhan
Feb 1, 2014·Evolution, Medicine, and Public Health·Ademir Jesus MartinsAlexandre Afranio Peixoto
Jan 5, 2011·Insect Biochemistry and Molecular Biology·Nongkran LumjuanHilary Ranson
Aug 27, 2015·Acta Tropica·Hélio Daniel Ribeiro RochaMaria Alice Varjal de Melo Santos
Oct 29, 2011·Insect Molecular Biology·Karla Saavedra-RodríguezWilliam C Black
Mar 27, 2013·Tropical Medicine & International Health : TM & IH·R BoyceO Horstick
Dec 5, 2013·Insect Molecular Biology·Karla Saavedra-RodríguezWilliam C Black
Oct 16, 2016·Pesticide Biochemistry and Physiology·Letícia B SmithJeffrey G Scott
Nov 6, 2012·Insect Biochemistry and Molecular Biology·Theresia Estomih NkyaJean-Philippe David
Jul 21, 2011·Asian Pacific Journal of Tropical Medicine·Sarita KumarMkk Pillai
Apr 7, 2015·Journal of the American Mosquito Control Association·Steven DenhamKarla Saavedra-Rodríguez
Feb 12, 2014·Acta Tropica·Danilo Oliveira CarvalhoMargareth Lara Capurro
Nov 21, 2015·PLoS Neglected Tropical Diseases·Isabelle DusfourClare Strode
Sep 19, 2014·PLoS Neglected Tropical Diseases·Fernando A MonteiroJeffrey R Powell
Aug 6, 2016·Journal of Medical Entomology·Gustavo Ponce-GarciaAdriana E Flores
Jan 30, 2014·Memórias do Instituto Oswaldo Cruz·Gonçalo SeixasCarla A Sousa
Nov 6, 2014·The American Journal of Tropical Medicine and Hygiene·Karla Saavedra-RodríguezWilliam C Black
Jul 21, 2017·PLoS Neglected Tropical Diseases·Catherine L MoyesDavid Weetman
Feb 23, 2019·PloS One·Yashoda KandelImmo A Hansen
Feb 14, 2019·Insect Molecular Biology·Karla Saavedra-RodríguezWilliam C Black
Jun 25, 2019·PloS One·Tri Baskoro Tunggul Satoto Kuswati
Dec 15, 2015·PLoS Neglected Tropical Diseases·Farah Z Vera-MaloofWilliam C Black IV
Apr 18, 2020·PLoS Neglected Tropical Diseases·Yinjun FanJeffrey G Scott
May 8, 2020·Archives of Insect Biochemistry and Physiology·Mengli ChenKe Dong
Jul 20, 2016·PLoS Neglected Tropical Diseases·Diane B ChoiNicole L Achee
Apr 18, 2020·Journal of Medical Entomology·Casey ParkerC Roxanne Connelly
Mar 30, 2017·Parasites & Vectors·Oscar Alexander Aguirre-ObandoMário Antônio Navarro-Silva
Sep 4, 2018·BioMed Research International·Michelangelo AuteriAlessandra Torina
Jul 4, 2018·Proceedings of the National Academy of Sciences of the United States of America·Marie MiglianicoKoen J Dechering
Jan 24, 2019·BioMed Research International·Penny Humaidah HamidCarlos Hermosilla
Nov 20, 2016·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Xing WeiXuelian Chang
May 15, 2018·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Nguyen Thi Kim LienNguyen Thi Huong Binh