PMID: 8450424Mar 1, 1993Paper

Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-c]pyridazine and its hydrazone derivatives

Journal of Pharmaceutical Sciences
J Gil-LongoC Teran

Abstract

3-Hydrazinocycloheptyl[1,2-c]pyridazine (4) and its hydrazone derivatives 3-[N1-(isopropylidene)]hydrazinocycloheptyl[1,2-c]pyridazine [correction of hydrazinocyclohexyl] (5) and 3-[N1-(isobutylidene)]hydrazinocycloheptyl[1,2-c]pyridazine (6) were prepared, and their activity against genetic, neurogenically-induced, and deoxycorticosterone acetate -NaCl-induced hypertension was found to be at least as great as that of hydralazine. The results of studying vasorelaxation of rat aorta by 4 and hydralazine suggest that both these compounds owe their antihypertensive activity to direct relaxation of vascular smooth muscle.

Citations

Mar 29, 2014·Journal of Enzyme Inhibition and Medicinal Chemistry·Nadia G Kandile, Howida T Zaky
May 23, 2012·European Journal of Medicinal Chemistry·Ziwen WangQingmin Wang
Oct 2, 2003·Biological & Pharmaceutical Bulletin·Ramaiah SivakumarJoseph Thomas Leonard
Mar 18, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Burcu Caliskan-ErgünSibel Suzen

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