PMID: 11903843Mar 21, 2002Paper

Pyridoxine-dependent seizures: a case report and a critical review of the literature

Journal of Paediatrics and Child Health
V K GuptaK K Singh

Abstract

Pyridoxine-dependent seizures are a recognized, although rare, cause of intractable seizures in neonates. Patients with this autosomal recessive disorder have recurrent seizures that are resistant to conventional anticonvulsants but respond dramatically to intravenous administration of pyridoxine. Life-long supplementation with pyridoxine is required to prevent seizure recurrence. In the absence of a biological marker for the disease, clinical diagnosis is often delayed and severe neurological sequelae are common. Herein, we report on the clinical course of a neonate with pyridoxine-dependent seizures. Delayed normalization of the electroencephalogram and a normal developmental outcome (at 15 months of age) on a dose of 10 mg/kg pyridoxine are distinctive features of the present case. We also review recent clinical observations and neurochemical studies that have added to our knowledge of this disorder.

Citations

Jul 15, 2005·Journal of Paediatrics and Child Health·Kathryn Browning Carmo, Peter Barr
Sep 11, 2010·Indian Journal of Pediatrics·Devendra MishraNarayan Saha
Mar 11, 2016·Journal of Pediatric Neurosciences·Mehtab IqbalSantosh R Mordekar
Oct 24, 2007·Emergency Medicine Clinics of North America·Kenneth T Kwon, Virginia W Tsai
Sep 8, 2004·Pediatric Neurology·Hüseyin TanCahit Karakelleoğlu
Aug 28, 2015·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·R RiikonenE Gaily
Apr 6, 2007·Seizure : the Journal of the British Epilepsy Association·L K TeuneD A Sival
Dec 12, 2012·Epilepsy & Behavior : E&B·Yoav NoamGregory L Holmes
Apr 23, 2005·The Cochrane Database of Systematic Reviews·L N Ranganathan, S Ramaratnam

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