Pyridyl-substituted corrole isomers: synthesis and their regulation to G-quadruplex structures

Chemistry, an Asian Journal
Heng MaXiang Zhou

Abstract

G-quadruplex DNA plays an important role in the potential therapeutic target for the design and development of anticancer drugs. As various G-quadruplex sequences in the promoter regions or telomeres can form different secondary structural modes and display a diversity of biology functions, variant G-quadruplex interactive agents may be necessary to cure different disease by differentiating variant types of G-quadruplexes. We synthesize five cationic methylpyridylium corroles and compare the interactions of corroles with different types of G-quadruplexes such as cmyc, htelo, and bcl2 by using surface plasmon resonance. Because of the importance of human telomere G-quadruplex DNA, we focus on the biological properties of the interactions between human telomere G-quadruplex DNA and corrole isomers using CD, T(m), PCR-stop (PCR= polymerase chain reaction), and polymerase-stop assay, which demonstrate the excellent ability of the corrole to induce and stabilize the G-quadruplex. This study provides the first experimental insight into how selectivity might be achieved for different G-quadruplexes by a single group of methylpyridylium corrole isomers that may be optimized for potential selective cancer therapy.

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Citations

Feb 20, 2016·The Journal of Membrane Biology·Zhen-Hua LiangXin-Yan Xiao
Jan 12, 2010·Bioorganic & Medicinal Chemistry·Yuhao DuXiang Zhou
Oct 21, 2016·Chemical Reviews·Ruijie D TeoHarry B Gray
Jul 2, 2011·Chemical Society Reviews·Pierre MuratEric Defrancq
Nov 30, 2018·Chemistry, an Asian Journal·Xudong WangFan Xia
Jul 27, 2011·Chemical Society Reviews·Gavin W Collie, Gary N Parkinson
Oct 23, 2010·Organic & Biomolecular Chemistry·Takayuki DoiTakashi Takahashi
May 23, 2013·Journal of the American Chemical Society·Alessandro D'UrsoRoberto Purrello
Jun 21, 2021·Chemical Biology & Drug Design·Nilanjan BanerjeeSubhrangsu Chatterjee
Jan 18, 2022·Chemical Society Reviews·Corrado Di NataleRoberto Paolesse

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