PMID: 8457800Jan 1, 1993Paper

Pyrimidine salvage pathways in Toxoplasma gondii

The Journal of Eukaryotic Microbiology
M H Iltzsch

Abstract

Pyrimidine salvage enzyme activities in cell-free extracts of Toxoplasma gondii were assayed in order to determine which of these enzyme activities are present in these parasites. Enzyme activities that were detected included phosphoribosyltransferase activity towards uracil (but not cytosine or thymine), nucleoside phosphorylase activity towards uridine, deoxyuridine and thymidine (but not cytidine or deoxycytidine), deaminase activity towards cytidine and deoxycytidine (but not cytosine, cytidine 5'-monophosphate or deoxycytidine 5'-monophosphate), and nucleoside 5'-monophosphate phosphohydrolase activity towards all nucleotides tested. No nucleoside kinase or phosphotransferase activity was detected, indicating that T. gondii lack the ability to directly phosphorylate nucleosides. Toxoplasma gondii appear to have a single non-specific uridine phosphorylase enzyme which can catalyze the reversible phosphorolysis of uridine, deoxyuridine and thymidine, and a single cytidine deaminase activity which can deaminate both cytidine and deoxycytidine. These results indicate that pyrimidine salvage in T. gondii probably occurs via the following reactions: cytidine and deoxycytidine are deaminated by cytidine deaminase to uridine and d...Continue Reading

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Citations

Mar 1, 1995·Molecular and Biochemical Parasitology·J C SchwabK A Joiner
Jan 30, 2002·Molecular and Biochemical Parasitology·Ida A Mejias-Torres, Barbara H Zimmermann
Sep 25, 1998·Molecular and Biochemical Parasitology·J R Radke, M W White
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·R G Donald, D S Roos
Oct 8, 1999·Biochemical Pharmacology·Z Z JavaidM H Iltzsch
May 15, 2012·Molecular and Biochemical Parasitology·Miryam Andrea Hortua TrianaBarbara H Zimmermann
May 25, 2016·Biochimica Et Biophysica Acta. General Subjects·Kinga Nyíri, Beáta G Vértessy
Apr 20, 2006·Molecular and Biochemical Parasitology·Sonia M Robles LopezBarbara H Zimmermann
Feb 23, 2002·Nature·L David Sibley
Feb 10, 2004·Microbiology·James K LithgowSimon J Foster
Apr 7, 2018·Frontiers in Cellular and Infection Microbiology·Heidy Y Narvaez-OrtizBarbara H Zimmermann
Mar 14, 2003·Biochimica Et Biophysica Acta·Maria L Sierra Pagan, Barbara H Zimmermann
Aug 8, 2021·International Journal of Molecular Sciences·Rajib AcharjeeDaniel K Inaoka

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