Pyrogenic reactions following gentamicin therapy: an alternative explanation

Medical Hypotheses
B L Jaber

Abstract

A hypothesis is proposed, arguing that gentamicin administration in a single daily dose results in higher peak tissue concentration, marked bacteriolysis with endotoxin (ET) release and consequent ET-mediated febrile host responses, which resemble Jarisch-Herxheimer reactions.

References

Sep 1, 1984·The Journal of Infectious Diseases·J L Shenep, K A Mogan
May 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Z Ali, M B Goetz
Mar 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S K ChuckD Areff
Feb 24, 2001·The New England Journal of Medicine·M M FanningT Piazza-Hepp

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Citations

May 4, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Manfred Hauben, Lester Reich
Jul 26, 2002·Pharmacoepidemiology and Drug Safety
Apr 3, 2014·Critical Care Nurse·Thomas Ahrens

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