PMID: 11900871Mar 20, 2002Paper

Pyrrolo[2,1-c][1,2,4]triazines from 2-diazopyrroles: synthesis and antiproliferative activity

European Journal of Medicinal Chemistry
Patrizia DianaGirolamo Cirrincione

Abstract

Pyrrolo[2,1-c][1,2,4]triazines 4a-g were directly obtained from the reaction of 2-diazopyrroles 1a and b with the sodium salts of beta-diketones, beta-carbonitriles, and beta-dinitriles. Only when the 2-diazopyrroles were coupled with ethyl cyanoacetate, it was possible to isolate, together with the pyrrolotriazines, the intermediate hydrazones 3 which, in turn, cyclised to the title ring system. Pyrrolotriazines 4a-e were evaluated for cytotoxic activity against a panel of 60 human cancer cell lines by the National Cancer Institute and some of them demonstrated inhibitory effects in the growth of a wide range of cancer cell lines generally at 10(-5) M level and in some cases at micromolar concentrations.

References

Jun 5, 1991·Journal of the National Cancer Institute·A MonksA Vaigro-Wolff
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S M O'ReillyP Lewis

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Citations

Jan 23, 2003·Bioorganic & Medicinal Chemistry·Maria T CoccoValentina Onnis
Jan 26, 2013·Chemical Reviews·Bagher Eftekhari-SisAli Akbari
Mar 15, 2015·European Journal of Medicinal Chemistry·Barbara ParrinoNadia Zaffaroni
Mar 18, 2015·European Journal of Medicinal Chemistry·Barbara ParrinoPatrizia Diana
Oct 24, 2007·European Journal of Medicinal Chemistry·Martine Varache-LembègeAlain Nuhrich
Jul 12, 2014·Pharmaceuticals·Catherine L Moody, Richard T Wheelhouse
Oct 1, 2011·Archiv der Pharmazie·Mosaad S MohamedSamar S Fathallah
Nov 21, 2019·Anti-cancer Agents in Medicinal Chemistry·Tarawanti VermaNitin Bansal
Nov 2, 2019·European Journal of Medicinal Chemistry·Hao LiuGao-Feng Zha

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