Pyrroloquinoline Quinone Decelerates Rheumatoid Arthritis Progression by Inhibiting Inflammatory Responses and Joint Destruction via Modulating NF-κB and MAPK Pathways

Inflammation
Zhongbing LiuDongmei Zhang

Abstract

Pyrroloquinoline quinone (PQQ) is a naturally occurring redox cofactor that acts as an essential nutrient and antioxidant and has been reported to exert potent immunosuppressive effects. However, the therapeutically potential of PQQ on rheumatoid arthritis (RA) has not been explored. In the present study, the anti-inflammatory effects of PQQ were investigated in interleukin (IL)-1β-treated SW982 cells, a RA-like fibroblast-like synoviocytes (FLSs) injury model. Our observations showed that pretreatment with PQQ significantly inhibited the expression of matrix metalloproteinase (MMP)-1 and MMP-3 and suppressed the production of proinflammatory mediators such as TNF-α and IL-6 in IL-1β-treated SW982 cells. The nuclear translocation of nuclear factor kappa B (NF-κB) and the phosphorylation level of p65, p38, and JNK MAP kinase pathways were also inhibited by PQQ in IL-1β-stimulated SW982 cells. To further confirm the therapeutic effects of PQQ on RA in vivo, a collagen-induced arthritis (CIA) model was used. Mice treated with PQQ demonstrated marked attenuation of arthritic symptoms based on histopathology and clinical arthritis scores. These results collectively suggested that PQQ might be a promising therapeutic agent for allevi...Continue Reading

References

Aug 30, 1979·Nature·S A SalisburyO Kennard
Sep 15, 1989·Biochemical and Biophysical Research Communications·P M GallopR Flückiger
Nov 15, 1995·Genes & Development·I M VermaS Miyamoto
Jan 3, 2001·The Journal of Clinical Investigation·P P Tak, G S Firestein
Mar 22, 2001·The New England Journal of Medicine·E H Choy, G S Panayi
Jun 9, 2001·Rheumatic Diseases Clinics of North America·Y Yamanishi, G S Firestein
Apr 23, 2003·Current Opinion in Rheumatology·Anja BaierThomas Pap
Jan 7, 2004·Nature Reviews. Drug Discovery·Michael KarinQ May Wang
Mar 25, 2004·In Vitro Cellular & Developmental Biology. Animal·Taisuke YamazakiTakayoshi Tokiwa
Jan 16, 2007·Nature Reviews. Immunology·V Hugh PerryClive Holmes
Feb 13, 2008·Cell·Matthew S Hayden, Sankar Ghosh
Jul 11, 2008·Immunological Reviews·Marc Feldmann, Sir Ravinder N Maini
Mar 24, 2009·Annual Review of Immunology·Sivakumar Vallabhapurapu, Michael Karin
Mar 3, 2010·Immunological Reviews·Beatrix Bartok, Gary S Firestein
Jul 6, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Eun Mi Choi, Young Soon Lee
Dec 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Olivier PascualAlain Bessis
Mar 24, 2012·Current Opinion in Neurobiology·João Peça, Guoping Feng
Mar 29, 2014·Forum on Immunopathological Diseases and Therapeutics·Robert Scheinman

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Citations

Apr 21, 2017·Food & Function·Maria Luisa CastejónCatalina Alarcón-de-la-Lastra
Oct 27, 2018·The British Journal of Nutrition·María Ángeles RosilloMarina Sánchez-Hidalgo
Dec 23, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Karen R JonscherJacob E Friedman
Dec 12, 2018·Current Stem Cell Research & Therapy·Hao WenBaorong He
Sep 15, 2019·Clinical and Experimental Pharmacology & Physiology·Jingjing HaoShijin Xia
Sep 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qi ZhangFei Ding
Mar 13, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lixia LiuQi Chen
Jun 19, 2021·Journal of Animal Science and Biotechnology·Caiyun HuangFenglai Wang

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