Pyrroloquinoline quinone (PQQ) has potential to ameliorate streptozotocin-induced diabetes mellitus and oxidative stress in mice: A histopathological and biochemical study

Chemico-biological Interactions
Narendra Kumar, Anand Kar

Abstract

Enhanced oxidative stress and hyperglycemia are associated with diabetes mellitus (DM). As pyrroloquinoline quinone (PQQ) is known to protect cells from oxidative stress, the present study was undertaken to reveal the hitherto unknown effects of PQQ in DM and associated problems in different tissues. Forty two mice were randomly divided into six groups. Group I receiving only citrate buffer served as the normal control, while group II animals were injected with citrate buffer and PQQ at 20 mg/kg for 15 days and served as test drug control. Animals of groups III-VI were rendered diabetic by single dose of streptozotocin (STZ, 150 mg/kg body weight), following which PQQ at a dose of 5, 10 and 20 mg/kg, was injected to the animals of group IV, V and VI respectively for 15 days. At the end, alterations in serum indices such as glucose, different lipids, insulin, amylase, urea, uric acid, serum glutamate pyruvate transaminase and serum glutamate oxaloacetate transaminase; tissue antioxidants and histopathological alterations in liver, kidney and pancreas were evaluated. STZ-treated animals developed oxidative stress as indicated by a significant increase in tissue lipid peroxidation (LPO) and lipid hydroperoxide, serum glucose, tota...Continue Reading

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Citations

Jan 7, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Gurkan YigitturkAltug Yavasoglu
Dec 23, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Karen R JonscherJacob E Friedman
Oct 5, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dilip ShahVineet Bhandari
Dec 14, 2018·Journal of Cellular Physiology·Elżbieta SupruniukBartłomiej Łukaszuk
Nov 12, 2020·International Journal of Molecular Sciences·Elżbieta SupruniukAdrian Chabowski

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