PMID: 476141Aug 22, 1979Paper

Pyruvate cycling involving possible oxaloacetate decarboxylase activity

Biochimica Et Biophysica Acta
R Rognstad

Abstract

With high concentrations of pyruvate as substrate for hepatocytes from fasted rats, high rates of cycling between pyruvate and the dicarboxylic acids occur, as shown isotopically. This rate of cycling is adequate to account for the hydrogen translocation from the mitochondria to the cytosol to furnish NADH for lactate formation. Addition of sufficiently high concentrations of mercaptopicolinate to block almost completely glucose formation from pyruvate, depresses isotopic cycling and lactate formation by only about 50-75%. Under some conditions, when the normal phosphoenolpyruvate carboxykinase activity is inhibited, cytosolic oxaloacetate may be decarboxylated directly to pyruvate, possibly via the decarboxylase activity of phosphoenolpyruvate carboxykinase.

References

Apr 21, 1975·Biochemical and Biophysical Research Communications·R Rognstad
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J E FeliúH G Hers
Oct 4, 1976·Biochemical and Biophysical Research Communications·T J van BerkelW C Hülsmann
Jun 23, 1976·Biochimica Et Biophysica Acta·R Rognstad, P Wals
Dec 1, 1975·Archives of Biochemistry and Biophysics·V KostosH L Saunders
Nov 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R N ZahltenH A Lardy
Mar 1, 1974·The Biochemical Journal·N W DiTullioH L Saunders
Dec 1, 1973·The Biochemical Journal·B Dean, W Bartley
Apr 2, 1974·Archives of Biochemistry and Biophysics·R Rognstad, D G Clark
Dec 1, 1971·European Journal of Biochemistry·R E SnokeH A Lardy
Sep 1, 1970·The Biochemical Journal·H F WoodsH A Krebs
Apr 1, 1971·Archives of Biochemistry and Biophysics·B FreidmannS Weinhouse

Citations

Jan 1, 1986·Kidney International·B D RossP Silva
Jan 1, 1986·Diabetes/metabolism Reviews·M D Meglasson, F M Matschinsky
Sep 1, 1983·Analytical Biochemistry·W L DillsG M McDonough
Jul 18, 1997·Biochemical and Biophysical Research Communications·J F Liang, T Akaike
Oct 15, 1982·Archives of Biochemistry and Biophysics·R Rognstad
Feb 1, 1985·The American Journal of Physiology·J K Kelleher

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