PMID: 2122529Sep 1, 1990Paper

Pyruvate dehydrogenase E1 alpha subunit genes in the mouse: mapping and comparison with human homologs

Somatic Cell and Molecular Genetics
R M BrownG K Brown

Abstract

Two gene loci for the E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex have been mapped in the mouse by in situ hybridization. One locus maps to the X chromosome in the region F3-F4, the other to chromosome 19, in band B close to the centromere. This arrangement is exactly comparable to the situation in man where there is an X-linked PDH E1 alpha locus and an autosomal locus on chromosome 4. Comparison of the regional localization of the human and mouse X-linked PDH E1 alpha genes provides further information concerning sites of rearrangement of segments of the X chromosome during mammalian evolution. The human autosomal PDH E1 alpha gene is a "processed" gene, which lacks the introns that are present in the X-linked gene. It codes for a testis-specific E1 alpha subunit that is only expressed after the onset of spermatogenesis. The comparative mapping results in the mouse suggest that the genetic organization and pattern of expression of the two PDH E1 alpha genes is the same in the two species.

References

Jan 1, 1989·Annals of the New York Academy of Sciences·G K BrownH H Dahl
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Citations

Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·H J BlairY Boyd
Jan 1, 1995·Virus Genes·J Brosius, H Tiedge
Jan 14, 1994·Brain Research. Developmental Brain Research·F Takakubo, H H Dahl
Oct 27, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·J JengB J Song
Jun 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Margarita Y LibRoderick A Capaldi
Oct 1, 1994·Molecular Reproduction and Development·R C IannelloI Kola
May 7, 2014·The Journal of Biological Chemistry·Mulchand S PatelFrank Jordan
May 7, 1992·Biochimica Et Biophysica Acta·J FitzgeraldH H Dahl

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