Pyruvate-enriched resuscitation for shock

Experimental Biology and Medicine
Robert T MalletRolf Bünger

Abstract

This commentary addresses the recent retraction of an article which reported favorable outcomes in septic patients treated with intravenous pyruvate. The retracted report was cited in the authors' recent minireview on the cellular mechanisms and clinical application of pyruvate to improve cardiac performance. Because the retracted article reports pyruvate-enhanced resuscitation of critically ill patients, the authors wish to inform the readership, especially critical care providers, that this particular clinical application of pyruvate is not now supported by robust evidence. After discussing the retraction's implications for the clinical application of pyruvate-enriched resuscitation for sepsis, this commentary summarizes the extensive preclinical evidence of the efficacy and mechanisms of pyruvate resuscitation in animal models of hemorrhagic and septic shock, which argues for renewed clinical investigation of pyruvate-enriched resuscitation. Impact statement This commentary addresses the recent retraction of a clinical report of significant benefits of intravenous pyruvate resuscitation in septic patients, including sharply lowered mortality and decreased circulating pro-inflammatory cytokines, which was cited in the authors...Continue Reading

References

Dec 22, 1999·The American Journal of Physiology·P D MonganR Bünger
Jan 27, 2011·Military Medicine·Devin C FlahertyRobert T Mallet
Jan 15, 2014·Experimental Biology and Medicine·Hunaid A GurjiRobert T Mallet
Jan 23, 2016·The American Journal of Emergency Medicine·Rui LiuZhi-Yong Sheng
Nov 21, 2017·Experimental Biology and Medicine·Robert T MalletRolf Bünger

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