Pyruvate is superior to reverse visceral hypoperfusion in peritoneal resuscitation from hemorrhagic shock in rats

Shock
Sen HuZhi-yong Sheng

Abstract

The objective of this study was to investigate the effects of pyruvate-containing fluids on peritoneal resuscitation (PR), following intravenous fluid resuscitation from hemorrhagic shock (HS) in rats. One hundred rats following 1-h HS with mean arterial pressure 35 ± 5 mmHg were randomly assigned to five groups (n = 10) in each of two comparable sets: group VR: intravenous resuscitation (VR) only and four groups with PR after VR: groups NS, LA, P1, and P2, resuscitated with normal saline, lactated peritoneal dialysis solution (PDS), pyruvated PDS, and 2.2% pyruvate, respectively. The splanchnic blood flow on surfaces of liver, kidney, and intestinal mucosa was detected. Blood samples were taken before HS and at T180 or T360 in these two animal sets after hemorrhage for function tests of liver, kidney, and intestinal mucosa, respectively. The intestinal mucosal barrier protein: zonula occludens 1 (ZO-1) and tissue water contents of these organs were also determined. Splanchnic blood flow was significantly preserved in all PR groups with hyperosmolar solutions: group P1 and group P2 with pyruvate were more advantageous than group LA. Group P2 was the most efficient among groups in reverse of visceral hypoperfusion. Organ functio...Continue Reading

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Citations

Jan 23, 2016·The American Journal of Emergency Medicine·Rui LiuZhi-Yong Sheng
Aug 6, 2014·The Journal of Surgical Research·Wen YuZhi-Yong Sheng
Mar 13, 2020·Experimental Biology and Medicine·Jing-Jing ZhangYan-Lin Wang
Dec 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yuxian ZhongGerhard Litscher
Mar 19, 2014·Shock·Mark G Clemens

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