Pyruvate kinase: current status of regulatory and functional properties

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Ma Enriqueta Muñoz, Elizabeth Ponce

Abstract

Pyruvate kinase (PK) is a key enzyme for the glycolytic pathway and carbon metabolism in general. On the basis of the relevance and enormous diverse properties of this enzyme, this paper describes the results of a current and extensive review that determines the sites of conservation and/or difference in PK sequences, and the differences in the functional and regulatory properties of the enzymes. An alignment and analysis of 50 PK sequences from different sources and a phylogenetic tree are presented. This analysis was performed with reference to crystallographically characterized PK principally from E. coli, cat and rabbit muscle. A number of attributes of the enzyme that make it of particular interest in biomedicine and industry are also discussed.

References

Jan 1, 1978·The International Journal of Biochemistry·E R Hall, G L Cottam
Sep 27, 1979·Biochemical and Biophysical Research Communications·S C JohnsonJ M Cardenas
Oct 15, 1979·Journal of Molecular Biology·D I StuartD K Stammers
Jan 1, 1977·Biochemical Society Transactions·D K StammersH Muirhead
Jun 25, 1975·Journal of Molecular Biology·D K Stammers, H Muirhead
Nov 20, 1992·Biochimica Et Biophysica Acta·F E Podestá, W C Plaxton
Dec 15, 1992·Biochemical and Biophysical Research Communications·N PuzenatM Raymondjean
Feb 1, 1992·Biochemical Society Transactions·S Potter, L A Fothergill-Gilmore
Feb 1, 1991·Biological Chemistry Hoppe-Seyler·G ValentiniG Ferri
Feb 15, 1989·Archives of Biochemistry and Biophysics·M LinW C Plaxton
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K TaniS Miwa
Jan 1, 1988·The International Journal of Biochemistry·M ImaraiJ Eyzaguirre
Jan 15, 1987·The Biochemical Journal·C Garcia-Olalla, A Garrido-Pertierra
Apr 1, 1986·Journal of Biochemistry·H SakaiK Imahori
Dec 2, 1985·European Journal of Biochemistry·E van SchaftingenH G Hers
May 1, 1969·The Biochemical Journal·M Benziman
Aug 1, 1983·Archives of Biochemistry and Biophysics·R Kapoor, T A Venkitasubramanian
Jan 1, 1982·Methods in Enzymology·M Malcovati, G Valentini
Sep 1, 1994·Molecular Microbiology·M H Saier, J Reizer
Sep 1, 1994·Computer Applications in the Biosciences : CABIOS·Y Van de Peer, R De Wachter
Jan 1, 1995·Plant Molecular Biology·S BlakeleyD T Dennis
Nov 1, 1994·Applied and Environmental Microbiology·G L Kleman, W R Strohl
Jun 15, 1994·Biochemical and Biophysical Research Communications·I ErnestP A Michels
Jul 1, 1994·Applied and Environmental Microbiology·M S JettenA J Sinskey
Jan 1, 1993·Progress in Biophysics and Molecular Biology·L A Fothergill-Gilmore, P A Michels

❮ Previous
Next ❯

Citations

Jul 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·James IngleseChristopher P Austin
Jul 21, 2005·Molecular Biology of the Cell·Beth F MitchellDavid R Mitchell
May 31, 2008·Journal of Biochemistry·Kenichiro SuzukiHiroshi Sakai
Mar 3, 2006·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Kenichiro SuzukiHiroshi Sakai
Jul 28, 2011·Photochemistry and Photobiology·Soheila MohammadiSaman Hosseinkhani
Aug 16, 2013·PLoS Computational Biology·Nadine VeithRebecca C Wade
Dec 10, 2013·Computational Biology and Chemistry·Aleksei KuznetsovJaak Järv
Aug 2, 2007·Journal of Industrial Microbiology & Biotechnology·Marjan De MeyErick Vandamme
Aug 17, 2010·Biochimica Et Biophysica Acta·Kay Ohlendieck
Jun 15, 2005·British Journal of Haematology·Elisa FermoAlberto Zanella
Sep 26, 2007·The Plant Journal : for Cell and Molecular Biology·Sébastien BaudChristine Rochat
Jan 31, 2009·Proteomics·Philip DoranKay Ohlendieck
Apr 3, 2012·Molecular Microbiology·Thomas H Hohle, Mark R O'Brian
Apr 2, 2016·Biochimica Et Biophysica Acta·Venugopal Reddy BovillaAnitha Mamillapalli
May 7, 2005·American Journal of Human Genetics·Ganesh SriramKatrina M Dipple
Mar 21, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Katherine A Johansen, Ken Overturf
Nov 2, 2007·Differentiation; Research in Biological Diversity·Andreas TrawegerHannelore Bauer
Jun 29, 2005·British Journal of Haematology·Alberto ZanellaGiovanna Valentini
Mar 31, 2015·Experimental Parasitology·Bidyadhar DasVeena Tandon
Jun 19, 2012·International Immunopharmacology·Renato A S OliveiraRodolfo C Garcia
Apr 9, 2015·Diseases of Aquatic Organisms·Sergio Fernández-BooAsunción Cao
Feb 11, 2014·Cancer Letters·Nicholas WongDamu Tang
Mar 12, 2013·International Journal of Cell Biology·Nicholas WongDamu Tang
Feb 14, 2006·Biochemical and Biophysical Research Communications·Choong-Il KimMi-Young Lee
Mar 27, 2015·PloS One·Gustavo De la Vega-RuízLeticia Ramírez-Silva
Mar 20, 2014·Physiological and Biochemical Zoology : PBZ·Christophe M R LeMoinePatrick J Walsh
Apr 1, 2017·Journal of Mathematical Biology·Laurent TournierVincent Fromion

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.