Pyruvate kinase deficiency and malaria

The New England Journal of Medicine
Kodjo AyiKevin C Kain

Abstract

Malaria that is caused by Plasmodium falciparum is a significant global health problem. Genetic characteristics of the host influence the severity of disease and the ultimate outcome of infection, and there is evidence of coevolution of the plasmodium parasite with its host. In humans, pyruvate kinase deficiency is the second most common erythrocyte enzyme disorder. Here, we show that pyruvate kinase deficiency provides protection against infection and replication of P. falciparum in human erythrocytes, raising the possibility that mutant pyruvate kinase alleles may confer a protective advantage against malaria in human populations in areas where the disease is endemic.

References

Aug 20, 1976·Science·W Trager, J B Jensen
Feb 1, 1991·The American Journal of Tropical Medicine and Hygiene·E PongponratnM Aikawa
Aug 5, 2000·Baillière's Best Practice & Research. Clinical Haematology·A Zanella, P Bianchi
Nov 5, 2003·Nature Genetics·Gundula Min-OoPhilippe Gros
Jan 15, 2004·The Journal of Infectious Diseases·Samir N PatelKevin C Kain
Mar 24, 2005·Infection and Immunity·Kodjo AyiKevin C Kain
May 13, 2005·Cellular Microbiology·Gundula Min-Oo, Philippe Gros
Jun 29, 2005·British Journal of Haematology·Alberto ZanellaGiovanna Valentini
Sep 3, 2005·Trends in Parasitology·Geoffrey A Targett
Mar 7, 2006·Current Molecular Medicine·Benjamin Mordmüller, Peter G Kremsner
Jul 4, 2006·Current Opinion in Microbiology·Thomas N Williams

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Citations

Dec 1, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Rhea LongleyPhilippe Gros
Mar 26, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Gundula Min-Oo, Philippe Gros
Apr 19, 2008·The New England Journal of Medicine·Johanna P Daily, Pardis Sabeti
Aug 30, 2008·The Journal of Infectious Diseases·Sunil Parikh, Philip J Rosenthal
May 21, 2011·Antioxidants & Redox Signaling·Sebastian KehrKatja Becker
Mar 12, 2009·Current Opinion in Pulmonary Medicine·Vannan Kandi Vijayan
May 19, 2010·Antimicrobial Agents and Chemotherapy·Gundula Min-OoPhilippe Gros
Oct 19, 2011·Hematology Reports·Sandro Eridani
Dec 24, 2013·Cellular and Molecular Life Sciences : CMLS·Lawrence R GrayEric B Taylor
Jan 1, 2010·Malaria Research and Treatment·Gunanidhi DhangadamajhiManoranjan Ranjit
Aug 13, 2011·Genes and Immunity·J BerghoutP Gros
Feb 10, 2016·Frontiers in Immunology·Josué da Costa Lima-Junior, Lilian Rose Pratt-Riccio
Jul 27, 2010·Gene·Carolina LópezManuel A Patarroyo
Mar 12, 2010·Experimental Parasitology·Gundula Min-OoPhilippe Gros
Oct 20, 2009·Blood Cells, Molecules & Diseases·Joana AlvesAna Paula Arez
Sep 1, 2009·Trends in Parasitology·Silayuv E BongfenPhilippe Gros
May 16, 2009·Current Opinion in Immunology·Anthony C Allison
Jun 20, 2015·American Journal of Hematology·Rachael F GraceBertil Glader
May 29, 2012·IUBMB Life·Janina PreussKatja Becker
Apr 10, 2010·British Journal of Haematology·Patrícia MachadoAna Paula Arez
Jan 15, 2013·Journal of Tropical Medicine·Vitor R R de MendonçaManoel Barral-Netto
Jun 26, 2012·International Journal for Parasitology·Amy K Bei, Manoj T Duraisingh
Aug 22, 2012·The Biochemical Journal·Hugh P MorganMalcolm D Walkinshaw
Jun 13, 2017·The Journal of Infectious Diseases·Imad FaikThirumalaisamy P Velavan
Oct 26, 2018·American Journal of Hematology·Paola BianchiUNKNOWN with the endorsement of EuroBloodNet, the European Reference Network in Rare Hematological Diseases
Mar 29, 2014·Current Opinion in Hematology·Steve M Taylor, Rick M Fairhurst
Mar 14, 2020·Haematologica·Hanny Al-SamkariRachael F Grace
Jul 25, 2020·Haematologica·Paola Bianchi, Elisa Fermo
Jul 24, 2020·Blood·Rachael F Grace, Wilma Barcellini

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