PMID: 3766523Nov 1, 1986Paper

Pyruvate kinase deficiency in dog and human erythrocytes: effects of energy depletion on cation composition and cellular hydration

American Journal of Hematology
A Muller-SoyanoB E Glader

Abstract

Pyruvate kinase-(PK) deficient human reticulocytes incubated 4 hr under conditions where mitochondrial oxidative phosphorylation is inhibited become ATP-depleted. Concomitantly, these energy-depleted red blood cells (RBC) lose massive amounts of potassium and water. PK-deficient reticulocyte-rich RBC from a Basenji dog, incubated under the same conditions, also manifest ATP-depletion and K-loss. In contrast to the cation changes in human cells, however, K-loss in PK-deficient dog reticulocyte-rich RBC is balanced by an equivalent Na gain, and consequently these canine erythrocytes do not undergo any change in cellular hydration. Potassium depletion and dehydration, which may be related to membrane injury in human RBC, do not appear to be involved in the hemolysis of PK-deficient dog erythrocytes.

References

Dec 1, 1978·British Journal of Haematology·B E GladerD G Nathan
Apr 22, 1976·The New England Journal of Medicine·B E Glader
Sep 5, 1974·The New England Journal of Medicine·B E GladerD G Nathan
May 1, 1971·The Journal of Physiology·P J Romero, R Whittam
Mar 1, 1971·The Journal of Clinical Investigation·W C MentzerD G Nathan
Nov 1, 1966·The American Journal of Medicine·A S Keitt
Jan 11, 1968·The New England Journal of Medicine·D G NathanF H Gardner

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Citations

Jan 1, 1992·Journal of Inherited Metabolic Disease·J W HarveyG A Dunaway
Jun 1, 1990·NMR in Biomedicine·G S PayneG K Radda

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