Pyruvate kinase M2 at a glance

Journal of Cell Science
Weiwei Yang, Zhimin Lu

Abstract

Reprogrammed metabolism is a key feature of cancer cells. The pyruvate kinase M2 (PKM2) isoform, which is commonly upregulated in many human cancers, has been recently shown to play a crucial role in metabolism reprogramming, gene transcription and cell cycle progression. In this Cell Science at a glance article and accompanying poster, we provide a brief overview of recent advances in understanding the mechanisms underlying the regulation of PKM2 expression, enzymatic activity, metabolic functions and subcellular location. We highlight the instrumental role of the non-metabolic functions of PKM2 in tumorigenesis and evaluate the potential to target PKM2 for cancer treatment.

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Citations

Apr 5, 2016·Archives of Biochemistry and Biophysics·Hong-Sheng ZhangYing-Hui Huang
Apr 23, 2016·Cell Cycle·Xinjian LiZhimin Lu
Apr 19, 2016·International Journal of Molecular Sciences·Yushuang DingYing Cheng
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Nov 1, 2018·Cancer Communications·Yugang WangZhimin Lu
Nov 14, 2019·International Journal of Molecular Sciences·Prasanta DeyHyung Sik Kim
May 17, 2017·The Journal of Experimental Medicine·Yan XiaZhimin Lu
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Oct 19, 2017·Nature Communications·Jong-Ho LeeZhimin Lu
Jun 23, 2018·Nature Reviews. Molecular Cell Biology·Xinjian LiZhimin Lu
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