Q fever: a new cause of 'doughnut' granulomatous lobular panniculitis

The British Journal of Dermatology
C GalacheJ Soto

Abstract

Q fever is an uncommon zoonotic rickettsial disease with no exanthem or specific cutaneous lesions. Only nonspecific cutaneous involvement has been reported to date. A 69-year-old Spanish woman with chronic myelogenous leukaemia developed fever and two subcutaneous nodules. The patient complained of extreme pain. Biopsy revealed a granulomatous lobular panniculitis with a characteristic 'fibrin ring' or 'doughnut' appearance: fibrin and inflammatory cells arranged around a central clear space. Changes of membranous lipodystrophy were also found. Q fever serological studies were positive. Our patient had panniculitis with singular histopathological features. These histopathological changes have been described in liver and bone marrow of patients with Q fever. To the best of our knowledge, this cutaneous involvement due to Q fever has not previously been described in the literature.

References

Jan 1, 1979·American Journal of Clinical Pathology·D B OkunK R Tanaka
Jul 1, 1991·International Journal of Dermatology·I BetllochA Vilar
May 1, 1988·Human Pathology·M NenertE S Zafrani
Oct 1, 1988·Gastroenterology·A MorenoJ A Vargas
Jan 1, 1980·Human Pathology·M PellegrinJ J Voigt
Oct 1, 1994·Journal of the American Academy of Dermatology·S I Chun, K Y Chung

❮ Previous
Next ❯

Citations

Jan 3, 2012·The Pediatric Infectious Disease Journal·Anita CohnClare Nourse
Dec 20, 2011·Actas dermo-sifiliográficas·M Llamas-VelascoJ Sánchez-Pérez
Dec 1, 2009·La Revue de médecine interne·C LandaisS Mouly
Nov 18, 2008·Médecine et maladies infectieuses·M MillionD Raoult
Sep 16, 2009·Journal of Cutaneous Pathology·R SoulardB Fouet
Aug 26, 2009·The International Journal of Lower Extremity Wounds·Uwe WollinaThomas Kittner
Nov 20, 2016·Clinical Microbiology Reviews·Carole EldinDidier Raoult
Aug 19, 2017·Infection·E MeriglierC Landron
Oct 12, 2020·International Journal of Dermatology·Eran ShavitAfsaneh Alavi
Apr 15, 2021·Virchows Archiv : an International Journal of Pathology·Annette BauerTibor Tot

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.