QacA multidrug efflux pump from Staphylococcus aureus: comparative analysis of resistance to diamidines, biguanidines, and guanylhydrazones.

Antimicrobial Agents and Chemotherapy
B A MitchellR A Skurray

Abstract

The staphylococcal multidrug efflux pump QacA mediates resistance to a broad spectrum of monovalent and divalent antimicrobial cations. Resistance toward various classes of these compounds identified features of the substrate that may be important for interaction with QacA. Analysis of combinations of two substrates suggested that the same mechanism is used for the extrusion of different classes of compounds.

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Citations

Apr 15, 2003·Clinical Microbiology Reviews·Peter Gilbert, Andrew J McBain
Jun 29, 2001·Seminars in Cell & Developmental Biology·S GrkovicR A Skurray
May 19, 2012·International Journal of Molecular Sciences·Sanath Kumar, Manuel F Varela
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Nov 29, 2002·Microbiology and Molecular Biology Reviews : MMBR·Steve GrkovicRonald A Skurray
May 13, 2005·Oral Diseases·S A Souza-Júnior, M A A Castro-Prado
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Oct 16, 2019·Mini Reviews in Medicinal Chemistry·Juliana de Oliveira Carneiro BrumJosé Daniel Figueroa Villar
Jul 28, 2010·Antimicrobial Agents and Chemotherapy·Hidemasa NakaminamiMasanori Sasatsu
Sep 4, 2014·Environmental Technology·Cees van SlootenAnita G J Buma
Feb 26, 2004·Antimicrobial Agents and Chemotherapy·Jianzhong HuangDamien McDevitt
Jan 24, 2020·PLoS Pathogens·Sarah Ben MaamarErica M Hartmann
Nov 12, 2005·The Journal of Biological Chemistry·Zhiqiang XuMelissa H Brown
Oct 25, 2006·Antimicrobial Agents and Chemotherapy·Christopher J IoannouStephen P Denyer
Apr 6, 2007·Biological & Pharmaceutical Bulletin·Fereshteh ShahcheraghiTomofusa Tsuchiya
Jan 22, 2003·Biochemical and Biophysical Research Communications·Lorenzo GalluzziMatti Karp
Aug 2, 2005·Biochemical and Biophysical Research Communications·Curtis W Sikora, Raymond J Turner
Jul 10, 2015·ACS Infectious Diseases·Megan C JenningsWilliam M Wuest

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