Qatari DNA variation at a crossroad of human migrations

Human Heredity
Ana M Pérez-MirandaRene J Herrera

Abstract

Genomic diversity of the Qatari population was investigated by screening 15 autosomal short tandem repeats (STRs). Significant departures from genetic equilibrium were detected at the D13S317, D19S433 and VWA loci, which persisted after applying Bonferroni-type corrections. Gene diversity (GD) values ranged from 0.6851 (TPOX) to 0.8813 (D2S1338), while observed heterozygosity (Ho) oscillated between 0.3388 (D19S433) and 0.8397 (D2S1338). Interestingly, Ho was lower than expected (He) for 14 of the loci analyzed. The information provided by these microsatellite markers was analyzed by means of genetic distances, multidimensional scaling, hierarchical analyses of the molecular variance (AMOVA) and admixture estimations to assess the genetic relationships of Qatar with European, Asian, African and other Middle Eastern populations. The main findings of the study were the genetic uniqueness of the Qatari population, its strong similarity to the United Arab Emirates (UAE) group, a slight genetic differentiation with respect to other Arab populations (Syria and Egypt) and Turkey, and a certain genetic affinity with sub-Saharan African populations. These results are discussed in light of two major issues: the high consanguinity rates c...Continue Reading

References

Aug 1, 1992·Trends in Genetics : TIG·C M HearneJ A Todd
Feb 1, 1991·American Journal of Physical Anthropology·J C LongU Iwaniec
Apr 1, 1972·Journal - Forensic Science Society·D A Jones
Mar 31, 1994·Nature·A M BowcockL L Cavalli-Sforza
Jan 1, 1995·Genetics·D B GoldsteinM W Feldman
Oct 1, 1994·Annals of Human Genetics·E Tunçbílek, I Koc
Jan 29, 1993·Science·L L Cavalli-SforzaA Piazza
Mar 1, 1996·The Journal of Pathology·J KorethJ O'D McGee
Jan 1, 1997·Human Genetics·A Pérez-LezaunJ Bertranpetit
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·L B JordeH C Harpending
Jun 1, 1997·Genome Research·M D ShriverR Deka
Jan 23, 1998·Forensic Science International : Synergy·I M Sebetan, H A Hajar
Sep 2, 1998·Forensic Science International : Synergy·I M Sebetan, H A Hajar
Jan 9, 1999·American Journal of Physical Anthropology·M M Lahr, R A Foley
Nov 27, 1999·Current Biology : CB·T KivisildR Villems
Dec 2, 1999·Nature Genetics·L Quintana-MurciA S Santachiara-Benerecetti
May 16, 2000·Nature·C Stringer
Jun 15, 2000·European Journal of Human Genetics : EJHG·E BoschJ Bertranpetit
May 12, 2001·Forensic Science International : Synergy·P SanzM J Farfán
Jun 21, 2001·Annals of Human Genetics·P A UnderhillL L Cavalli-Sforza
Sep 13, 2001·Clinical Genetics·A Bittles
Sep 17, 2002·Forensic Science International : Synergy·M Y LawK L Chan
Apr 11, 2003·American Journal of Physical Anthropology·G Lucotte, G Mercier
Jun 6, 2003·Forensic Science International : Synergy·M HashiyadaM Funayama
Jun 6, 2003·Forensic Science International : Synergy·Diane J Rowold, Rene J Herrera
Aug 2, 2003·Forensic Science International : Synergy·A Hadi CakirEmel Yardimci
Sep 13, 2003·Forensic Science International : Synergy·Yoo-Li KimDong-Wook Kim
Oct 11, 2003·Forensic Science International : Synergy·Ioulia SkitsaAngel Carracedo
Dec 4, 2003·Forensic Science International : Synergy·Chih-Wei WangChien-Feng Sun
Dec 4, 2003·Forensic Science International : Synergy·Lay Hong SeahSue Sing Kee
Dec 24, 2003·American Journal of Human Genetics·Lev A ZhivotovskyLuba Kalaydjieva
Feb 20, 2004·American Journal of Human Genetics·J R LuisR J Herrera
Mar 11, 2004·Annals of Human Genetics·D ComasH Schmidt
Mar 26, 2004·Forensic Science International : Synergy·Ronny DecorteJean-Jacques Cassiman
Apr 6, 2004·Forensic Science International : Synergy·S BelezaL Gusmão
Jul 9, 2004·Forensic Science International : Synergy·Witold PepinskiIreneusz Soltyszewski
Jun 28, 2005·Forensic Science International : Synergy·A M Pérez-MirandaR J Herrera
Jul 1, 1985·Evolution; International Journal of Organic Evolution·Joseph Felsenstein

❮ Previous
Next ❯

Citations

Dec 15, 2007·Journal of Human Genetics·M RegueiroR J Herrera
Mar 14, 2009·Journal of Human Genetics·Tenzin GaydenRene J Herrera
May 9, 2009·Journal of Human Genetics·Muthukrishnan EaaswarkhanthIkramul Haque
Sep 12, 2009·Journal of Human Genetics·Maria C TerrerosRene J Herrera
Oct 12, 2007·European Journal of Human Genetics : EJHG·Alicia M CadenasRene J Herrera
Oct 15, 2013·Gene·Ralph Garcia-BertrandRene J Herrera
Aug 2, 2011·Forensic Science International. Genetics·Samir ElmrghniD Ross Williams
Jan 18, 2011·Legal Medicine·Harlette LacauRene J Herrera
Feb 14, 2009·Forensic Science International. Genetics·Ghada A OmranMark A Jobling
Dec 2, 2009·Forensic Science International. Genetics·Aisha Al-ObaidliRajagopal Krishnamoorthy
Nov 15, 2007·American Journal of Physical Anthropology·Lisa Ibarra-RiveraRene J Herrera
Feb 27, 2013·American Journal of Physical Anthropology·Sheyla MirabalRene J Herrera
Aug 10, 2011·American Journal of Physical Anthropology·Robert K LoweryRene J Herrera
Jun 4, 2010·International Journal of Immunogenetics·S García-ObregónJ A Peña
Jul 11, 2009·American Journal of Physical Anthropology·Wen-Zhi WangYa-Ping Zhang
Feb 11, 2011·Journal of Human Genetics·Diana M MorloteRene J Herrera
Oct 25, 2007·American Journal of Human Biology : the Official Journal of the Human Biology Council·M A Alfonso-SánchezR J Herrera
Jan 4, 2008·American Journal of Human Biology : the Official Journal of the Human Biology Council·M A Alfonso-SánchezM M De Pancorbo
Feb 20, 2019·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Na-Yon KimYongbaek Kim
Nov 14, 2013·International Journal of Food Sciences and Nutrition·Raúl E CianSilvina R Drago
Apr 2, 2015·Indian Journal of Ophthalmology·M L PandeyA Sharma
Jan 6, 2016·Genome Research·Juan L Rodriguez-FloresJason G Mezey
Jan 1, 2014·Global Cardiology Science & Practice·Ghazi O TadmouriLotfi Chouchane
Apr 17, 2007·American Journal of Human Genetics·Tenzin GaydenRene J Herrera
Jan 25, 2022·Annals of Human Biology·Rim Al-Haj-TaibKarima Fadhlaoui-Zid

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.