PMID: 7542289Apr 1, 1995Paper

QBEND10 for the diagnosis of myelodysplastic syndromes in routinely processed bone marrow biopsy specimens

Journal of Clinical Pathology
H-P HornyE Kaiserling

Abstract

The assessment of the value of the antibody QBEND10, which is directed against the haemopoietic stem cell related antigen CD34, in the immunohistochemical diagnosis of myelodysplastic syndrome in routinely processed bone marrow biopsy specimens. 581 formalin fixed, paraffin embedded trephine biopsy specimens of the iliac crest were immunostained with QBEND10 (avidin-biotin complex/ABC method). The number of CD34+ haemopoietic stem cells/blast cells (referred to hereafter as CD34+ cells) was determined in each case. The Wilcoxon test was used for statistical analysis. The following diagnostic categories were defined: (1) normal or reactive bone marrow (n = 356), (2) lymphoproliferative disorders, usually non-Hodgkin's lymphoma of low grade malignancy or multiple myeloma (n = 118), (3) myelodysplastic syndrome (n = 22), (4) acute leukaemia (n = 44), and (5) myeloproliferative diseases (n = 41). The average number of CD34+ cells was very low (0.2/HPF) in normal and reactive bone marrow, in lymphoproliferative disorders and in the myelodysplastic syndrome subtypes RA and RARS. Myeloproliferative diseases showed an average of three CD34+ cells/HPF. However, the average number of CD34+ cells was significantly higher (p < 0.05) in the...Continue Reading

References

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Citations

May 1, 1997·Journal of Clinical Pathology·W N ErberG J Hoffman
Oct 19, 2005·Virchows Archiv : an International Journal of Pathology·Marcus KremerFalko Fend
Sep 19, 2003·Wiener klinische Wochenschrift·Peter ValentKlaus Geissler
Jul 17, 2009·American Journal of Clinical Pathology·Attilio Orazi, Magdalena B Czader
Feb 5, 2008·Progress in Histochemistry and Cytochemistry·Falko FendStephan Dirnhofer
Jul 3, 2007·Leukemia Research·Hans-Peter HornyPeter Valent
Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E VerburghG Verhoef
Dec 24, 2018·Seminars in Hematology·Aaron HodesRaul Braylan
Jun 29, 2002·Archives of Pathology & Laboratory Medicine·Goran TorlakovicEmina Torlakovic

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