Qed-1--a target for unrestricted killing by T cells

European Journal of Immunology
K F Lindahl, B Hausmann

Abstract

Two prototype target determinants for unrestricted killing by T cells are defined: Qed-1a, detected on B6.Tlaa targets by C3H/HeJ lymphocytes primed in vivo and restimulated in vitro by B10.BR spleen cells; and Qed-1b, detected on C57BL/6J lymphocytes by B10.BR anti-C3H/HeJ effector cells generated in the same manner. Other mouse strains can be typed for Qed-1 by the ability of their lymphocytes to inhibit one of these lytic reactions. Of 55 inbred strains, 52 expressed either Qed-1a or Qed-1b, which thus behaved as products of alleles of a single locus, Qed-1. The remaining three strains, all H-2r, did not compete against specific lysis of Qed-1a, but inhibited Qed-1b-specific lysis only in part; it is proposed that these strains carry a third allele or haploype, Qed-1c. The Qed-1 locus was mapped distal to Qa-2. Qed-1b was found on both normal and mitogen-activated lymphocytes and did not appear confined to any lymphoid subpopulation. Cytotoxic responses, not restricted by H-2 and specific for antigens controlled by the Tla region, could be induced in several combinations of H-2-identical strains differing at Qed-1. Cells of some strains, like B10.BR, NZB, and SWR, responded directly in culture, even without priming in vivo.

References

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Citations

Jan 1, 1981·Immunogenetics·P DémantK Fischer-Lindahl
Jan 1, 1982·Immunogenetics·P J Wettstein, D W Bailey
Jan 1, 1981·Immunogenetics·L FlahertyK DiBiase
Mar 1, 1981·Immunogenetics·G BiasiL Chieco-Bianchi
Jan 1, 1980·Immunogenetics·K F Lindahl, B Hausmann
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K F Lindahl, K Bürki
Dec 1, 1980·The Journal of Experimental Medicine·K Fischer LindahlR Riblet
Jun 1, 1982·The Journal of Experimental Medicine·D H Raulet, M J Bevan
Nov 1, 1982·The Journal of Experimental Medicine·S Macphail, O Stutman
Dec 1, 1982·The Journal of Experimental Medicine·R SmithR R Rich
Oct 1, 1984·Journal of Immunogenetics·R A HarrisI F McKenzie
Feb 1, 1982·European Journal of Immunology·K F LindahlL Flaherty
Dec 1, 1981·Scandinavian Journal of Immunology·K F Lindahl, J Langhorne
Dec 1, 1981·Scandinavian Journal of Immunology·J C Howard, G W Butcher
Feb 1, 1982·European Journal of Immunology·J Langhorne, K F Lindahl
Sep 1, 1983·Tissue Antigens·S TewarsonJ Klein

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