Qinghaosu resistance in rodent malaria.

Transactions of the Royal Society of Tropical Medicine and Hygiene
A N ChawiraW Peters

Abstract

Resistance to qinghaosu (artemisinin) developed rapidly in a chloroquine-resistant line of Plasmodium yoelii (NS) passaged in mice, but was not produced in chloroquine-sensitive P. berghei. Development of resistance took place in an apparently stepwise fashion. After removal of drug selection pressure some resistance was lost which was regained rapidly within three passages when drug pressure was reapplied. The resistant QS line was cross-resistant to two reduced derivatives of artemisinin but not to propoxycarbonyl dihydroartemisinin or artesunate. No significant resistance was shown against primaquine, pyrimethamine, cycloguanil or pyrimethamine-sulphadoxine, but resistance to chloroquine was enhanced and marked resistance to quinine, mefloquine and amodiaquine was noted. It is suggested that the unusual cross-resistance pattern of the strain relates to changes in membrane characteristics.

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Citations

Oct 19, 1990·Pharmaceutisch Weekblad. Scientific Edition·H J WoerdenbagN Pras
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·A N ChawiraW Peters
Jan 1, 1990·Pharmacology & Therapeutics·W Peters
Aug 30, 2003·Molecular and Biochemical Parasitology·Gregory S NolandDavid J Sullivan
May 29, 2000·Parasitology Today·M L Willcox, G Bodeker
Jul 13, 2012·Proceedings. Biological Sciences·Eili Y KleinSimon Levin
Nov 16, 2011·Antimicrobial Agents and Chemotherapy·Matthew S TuckerDennis E Kyle
Mar 3, 2007·Chemical & Pharmaceutical Bulletin·Bruno Ndjakou LentaJoseph Donald Connolly
Dec 15, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Clara MenéndezAlfredo Mayor
Jan 7, 2015·Proceedings of the National Academy of Sciences of the United States of America·Mostafa A ElfawalStephen M Rich
Feb 20, 2013·International Journal for Parasitology. Drugs and Drug Resistance·Qin ChengMichelle L Gatton
Apr 6, 1999·Phytotherapy Research : PTR·J C SteeleM S Simmonds
Jun 3, 2009·Expert Review of Anti-infective Therapy·Hamza A BabikerGöte Swedberg
Oct 7, 2009·Expert Review of Anti-infective Therapy·Liwang Cui, Xin-zhuan Su
Oct 24, 2019·The American Journal of Tropical Medicine and Hygiene·Matthew R Hassett, Paul D Roepe
Oct 1, 1986·Annals of Tropical Medicine and Parasitology·W PetersD C Warhurst
Mar 1, 1997·Annals of Tropical Medicine and Parasitology·W Peters, B L Robinson
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Oct 1, 1987·Annals of Tropical Medicine and Parasitology·R E Howells
Nov 19, 2020·Infection and Drug Resistance·Melkamu Adigo ShibeshiSeyfe Asrade Atnafie

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