Qingre quyu granule stabilizes plaques through inhibiting the expression of tenascin-C in patients with severe carotid stenosis

Chinese Journal of Integrative Medicine
Yi WangJian Guo

Abstract

To investigate the therapeutic effects of Qingre Quyu Granule (QQG) on the patients with severe carotid stenosis, and to explore the mechanism of it. Ninety-six patients with severe carotid stenosis were enrolled in the study and were classified into a QQG group (n=48) and a control group (n=48) randomly using consecutively numbered envelopes. The patients in the QQG group were given QQG and Western medicine, those in the control group were given Western medicine merely, the course of treatment was 16 weeks. All patients went through endarterectomy after treatment. Plaques were subjected to the analysis of CD3, CD68, soluble intercellular adhesion molecule 1 (ICAM-1), matrix metalloprotease-9 (MMP-9), CD40L, tenascin-C, and collagen content lipid content by immunohistochemistry or polarized light analysis. By the end of experiment, the expressions of CD3, CD68, ICAM-1, MMP9, CD40L and tenascin-C on the plaques were statistically significant lower in the QQG group compared with the control group(P<0.01). The lipid content of the plaque was also significantly lower in the QQG group compared with the control group (P<0.01). The interstitial collagen in the tissue sections of the plaques was also significantly higher in the QQG gro...Continue Reading

References

Jun 3, 2006·Stroke; a Journal of Cerebral Circulation·Guido Stoll, Martin Bendszus
Oct 31, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jun-ichiro KogaKenji Sunagawa
Mar 24, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Daiju FukudaMasataka Sata
Jun 30, 2011·Cardiovascular Research·Jonathan GolledgeSimon Koblar
Oct 21, 2011·Thrombosis and Haemostasis·D Lievens, P von Hundelshausen
Nov 19, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Dorien M SchrijversWim Martinet
Jan 24, 2012·Circulation Research·Anne Angelillo-Scherrer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Related Papers

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
Wen-li ChengZhe Cai
Current Problems in Surgery
A D Whittemore
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
Zhi-Dong YeFeng-Lin Wang
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
R Nyberg-Hansen
© 2021 Meta ULC. All rights reserved