QRISK3 improves detection of cardiovascular disease risk in patients with systemic lupus erythematosus

Lupus Science & Medicine
Nicola EdwardsFiona L Wilkinson

Abstract

10-year cardiovascular disease (CVD) risk scores are calculated using algorithms, including Framingham (worldwide) and QRISK2 (UK). Recently, an updated QRISK3 model was introduced, which considers new variables including SLE and steroid prescription, not included in QRISK2 and Framingham algorithms. We sought to determine the extent to which QRISK3 improves identification of high-risk patients with SLE and whether the score relates to standard and novel markers of SLE-specific endothelial dysfunction. Framingham and QRISK2/3 scores were calculated in patients with SLE (n=109) and healthy controls (n=29) using clinical measures. In a smaller cohort (n=58), markers of inflammation and endothelial dysfunction, including CD144+ endothelial microvesicles (EMVs), triglycerides, vascular cell adhesion molecule (VCAM) and high-sensitivity C reactive protein (hsCRP) were quantified by flow cytometry and ELISA, respectively. Patients with SLE demonstrated significantly higher QRISK3 scores than controls (5.0%vs0.3%, p<0.001). 21/109 patients with SLE (19%) and 24/109(22%) were newly identified as being at high risk of a CV event when using QRISK3 versus QRISK2 (29vs8patients) and QRISK3 versus Framingham (29vs5patients; p<0.001), respec...Continue Reading

Citations

Jan 30, 2020·Current Vascular Pharmacology·Konstantinos MelissaropoulosDimitrios Daoussis
Nov 19, 2020·Cardiology Research and Practice·Brygida Przywara-ChowaniecEwa Nowalany-Kozielska
Sep 4, 2021·International Journal of Nephrology and Renovascular Disease·Yaser AmmarDalia Maharem
Jul 10, 2021·Rheumatology·Juan Carlos Quevedo-AbeledoIván Ferraz-Amaro
Jan 15, 2022·Current Cardiology Reports·Shrilekha SairamKunal Mishra

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