QRS fragmentation and sudden cardiac death in the obese and overweight

Journal of the American Heart Association
Kumar NarayananSumeet S Chugh

Abstract

Obesity has been associated with significantly greater risk of sudden cardiac death (SCD); however, identifying the obese patient at highest risk remains a challenge. We evaluated the association between QRS fragmentation on the 12-lead electrocardiogram and SCD, in obese/overweight subjects. In the ongoing prospective, community-based Oregon Sudden Unexpected Death Study (population approximately 1 million), we performed a case-control analysis, comparing obese/overweight SCD victims with obese/overweight controls from the same geographic region. Archived ECGs prior and unrelated to the SCD event were used for cases and all ECG measurements were assessed in blinded fashion. Fragmentation was defined as the presence of RSR' patterns and/or notching of the R/S wave in at least 2 contiguous leads. Analysis was limited to ECGs with QRS duration <120 ms. Overall prevalence of fragmentation was higher in cases (n=185; 64.9±13.8 years; 67.0% male) compared with controls (n=405; 64.9±11.0 years; 64.7% male) (34.6% versus 26.9%, P=0.06). Lateral fragmentation was significantly more frequent in cases (8.1% versus 2.5%; P<0. 01), with non-significant differences in anterior and inferior territories. Fragmentation in multiple territories ...Continue Reading

References

Apr 1, 1988·American Heart Journal·W B KannelL A Cupples
Nov 24, 1999·The American Journal of Cardiology·L L CrisostomoA Rabelo
Apr 20, 2001·The American Journal of the Medical Sciences·M A Alpert
Nov 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Saumya SharmaHeinrich Taegtmeyer
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Aug 4, 2005·Expert Review of Cardiovascular Therapy·Stephen A MorseEfrain Reisin
Jan 18, 2006·Journal of the American College of Cardiology·Sabine M J M StrausJacqueline C M Witteman
Oct 24, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mithilesh Kumar DasDouglas P Zipes
Jan 25, 2008·American Heart Journal·Nikolas WanahitaJonathan S Steinberg
Sep 12, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Stefan PetersBrigitte Koehler
Mar 11, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mithilesh K Das, Douglas P Zipes
Oct 8, 2009·Circulation. Arrhythmia and Electrophysiology·Mithilesh K DasJo Mahenthiran
Jan 28, 2010·American Heart Journal·A Selcuk AdabagRussell V Luepker
Feb 5, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mithilesh Kumar DasDeepak Bhakta
Jun 1, 2010·Circulation. Arrhythmia and Electrophysiology·Aamir CheemaPaul S Chan
Jul 4, 2012·International Journal of Cardiology·Stefano PerliniGiampaolo Merlini
Jul 19, 2012·Journal of Cardiovascular Electrophysiology·Andrew BrenyoWojciech Zareba
Mar 7, 2013·JAMA : the Journal of the American Medical Association·Ankur GulatiSanjay K Prasad
May 18, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Carmen TeodorescuSumeet S Chugh
May 21, 2013·International Journal of Cardiology·Amit NoheriaSumeet S Chugh
Feb 27, 2014·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
May 13, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ki-Woon KangHye Jin Hwang
Jun 13, 2014·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Fırat OzcanSinan Aydogdu
Jul 22, 2014·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Xin-wei YangShu Zhang

❮ Previous
Next ❯

Citations

Nov 3, 2015·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Bojun Gong, Zicheng Li
Jan 31, 2020·The American Journal of Forensic Medicine and Pathology·Anthony TuzzoloRobert Poppiti
Jul 18, 2019·Internal Medicine Journal·Ronpichai ChokesuwattanaskulWisit Cheungpasitporn
Jul 15, 2017·Current Obesity Reports·Asta LukosiuteJonathan Mark Cousins
May 21, 2019·International Heart Journal·Hui ChenShunhui Li
Feb 26, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Pierre OllitraultAmir Hodzic
Dec 31, 2020·Cardiology Research and Practice·Xufei LiangXuhong Geng
Apr 23, 2021·Circulation·Tiffany M Powell-WileyUNKNOWN American Heart Association Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular and Stroke Nursing; Co

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery disease

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.