QRS prolongation induced by cardiac resynchronization therapy correlates with deterioration in left ventricular function

Heart Rhythm : the Official Journal of the Heart Rhythm Society
John RickardNiraj Varma

Abstract

The benefits of cardiac resynchronization in inducing reverse ventricular remodeling in patients with left ventricular (LV) systolic dysfunction have been well established. Still, up to 30% of the patients fail to derive significant improvement from this therapy. A subset of "nonresponders" experience deterioration in LV function following cardiac resynchronization therapy (CRT). Characteristics of this patient population, however, have not been studied. To determine characteristics of patients who experience deterioration in LV function following CRT. Clinical, electrocardiographic, and echocardiographic data were collected in 856 consecutive patients presenting for a new CRT device. For inclusion, all patients had an LV ejection fraction '40%, a QRS duration '120 ms, and available baseline and follow-up echocardiograms and electrocardiograms. Deterioration in LV function was defined as an absolute decrease of 5% or greater in ejection fraction from baseline. Multivariate models were constructed to identify variables significantly associated with deterioration. A total of 507 patients met inclusion criteria, of which 60 (11.8%) met criteria for deterioration. Patients with deterioration were more likely to be men (86.7% vs 66....Continue Reading

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Citations

Feb 20, 2014·Current Treatment Options in Cardiovascular Medicine·John Rickard, Niraj Varma
Sep 18, 2014·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Xin-wei YangShu Zhang
May 23, 2014·Expert Review of Cardiovascular Therapy·Giuseppe StabileAntonio De Simone
Jun 16, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·J Claude DaubertChristophe Leclercq
Aug 12, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Daniel J FriedmanE Kevin Heist
Sep 24, 2015·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Jan De PooterRoland Stroobandt
Jul 22, 2014·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Xin-wei YangShu Zhang
Feb 19, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jacob M LarsenJens B Johansen
Jul 3, 2016·European Heart Journal·Claude DaubertChristophe Leclercq
Oct 25, 2016·The American Journal of Cardiology·Panagiotis KorantzopoulosTong Liu
Nov 26, 2016·Journal of Cardiovascular Electrophysiology·Jan DE PooterFrank Timmermans
Oct 11, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Marek JastrzebskiDanuta Czarnecka
Mar 16, 2017·European Journal of Heart Failure·Cecilia LindeJohn G Cleland
Apr 19, 2018·Current Heart Failure Reports·Adam GrimaldiJohn Rickard
Nov 8, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Marek JastrzebskiDanuta Czarnecka

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