QSAR analysis and molecular modeling of ABCG2-specific inhibitors

Advanced Drug Delivery Reviews
E NicolleAttilio Di Pietro

Abstract

In addition to its critical role is controlling drug availability and protecting sensitive organs and stem cells through cellular detoxification, breast cancer resistance protein (BCRP/ABCG2) plays an important role in cancer cell resistance to chemotherapy, together with P-glycoprotein/ABCB1. A main approach to abolish multidrug resistance is to find out specific inhibitors of the drug-efflux activity, able to chemosensitize cancer cell proliferation. Many efforts have been primarily focused on ABCB1, discovered thirty years ago, whereas very few studies have concerned ABCG2, identified much more recently. This review describes the main types of inhibitors presently known for ABCG2, and how quantitative structure-activity relationship analysis among series of compounds may lead to build up molecular models and pharmacophores allowing to design lead inhibitors as future candidates for clinical trials. A special attention is drawn on flavonoids which constitute a structurally-diverse class of compounds, well suited to identify potent ABCG2-specific inhibitors.

References

Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H L PearceW T Beck
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·S DeyS V Ambudkar
Mar 10, 1998·European Journal of Biochemistry·A Seelig
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·G ConseilA Di Pietro
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·L A DoyleD D Ross
Mar 30, 2000·International Journal of Clinical Pharmacology and Therapeutics·A SeeligF Wohnsland
Dec 21, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·A Seelig, E Landwojtowicz
Jan 5, 2001·Bioorganic & Medicinal Chemistry Letters·A van LoevezijnG J Koomen
Feb 13, 2001·Biochemical and Biophysical Research Communications·S KawabataS Kohno
Feb 24, 2001·Annals of the New York Academy of Sciences·J H SchellensA H Schinkel
Jun 19, 2001·Biochimica Et Biophysica Acta·R W RobeyS E Bates
Mar 28, 2002·Cellular and Molecular Life Sciences : CMLS·A Di PietroD Barron
Apr 19, 2002·Journal of Medicinal Chemistry·Julie E PenzottiPeter D J Grootenhuis
Apr 19, 2002·Molecular Pharmacology·Sean EkinsSteven A Wrighton
Nov 19, 2002·Molecular Pharmacology·Alexia GarriguesStéphane Orlowski
Jun 11, 2003·Journal of Clinical Pharmacy and Therapeutics·R B WangE J Lien
Aug 16, 2003·Molecular Pharmacology·Yasuo ImaiYoshikazu Sugimoto
Oct 21, 2003·International Journal of Cancer. Journal International Du Cancer·Holger WoehleckeHermann Lage
Nov 18, 2003·International Journal of Cancer. Journal International Du Cancer·Ken ShiozawaShigeru Kohno
Feb 20, 2004·Cancer Research·Robert W RobeySusan E Bates
Mar 5, 2004·Journal of Pharmaceutical Sciences·Vijay K GombarCosette S Serabjit-Singh
Mar 6, 2004·The Journal of Biological Chemistry·Junkang XuJian-Ting Zhang
Mar 27, 2004·The Journal of Biological Chemistry·Partha KrishnamurthyJohn D Schuetz
Mar 30, 2004·Biochemical and Biophysical Research Communications·Hiran C CoorayMargery A Barrand
Apr 23, 2004·Molecular Pharmacology·Shuzhong ZhangMarilyn E Morris
May 25, 2004·Molecular Pharmacology·Csilla Ozvegy-LaczkaBalázs Sarkadi
Jun 2, 2004·International Journal of Cancer. Journal International Du Cancer·Megumi YoshikawaShinzo Tanabe

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Citations

Mar 2, 2010·Nature Reviews. Drug Discovery·UNKNOWN International Transporter ConsortiumLei Zhang
Aug 14, 2010·The Journal of Biological Chemistry·Elodie Desuzinges-MandonPierre Falson
Mar 15, 2014·International Journal of Oncology·Rishil J KathawalaZhe-Sheng Chen
Jan 8, 2013·Expert Opinion on Drug Metabolism & Toxicology·Rebecca Schnepf, Oliver Zolk
Feb 4, 2016·European Journal of Medicinal Chemistry·Dana A AlQudahMutasem O Taha
Sep 30, 2010·Expert Opinion on Drug Metabolism & Toxicology·Maren PoguntkeOliver Zolk
Jun 30, 2011·Free Radical Biology & Medicine·Remy KachadourianBrian J Day
Jan 11, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·O ArnaudL Payen
Jun 9, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Edwige NicolleAhcène Boumendjel
Apr 15, 2014·The International Journal of Biochemistry & Cell Biology·Hui ZhangZhe-Sheng Chen
Sep 23, 2014·The AAPS Journal·Qingcheng Mao, Jashvant D Unadkat
Dec 15, 2011·Journal of Medicinal Chemistry·Glaucio ValdameriAttilio Di Pietro
Feb 16, 2020·Cancers·Rishil J KathawalaSteffan T Nawrocki
Jan 1, 2011·International Journal of Medicinal Chemistry·A B IvanovaJ Molnar

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