QSAR of clinically important EGFR mutant L858R/T790M pyridinylimidazole inhibitors

Chemical Biology & Drug Design
Shehnaz FatimaSubhash Mohan Agarwal

Abstract

EGFR is a well-established therapeutic target of clinical relevance in cancer. However, acquisition of secondary mutation (T790M) makes first-generation inhibitors ineffective. Therefore, to circumvent the problem of resistance, new T790M/L858R (TMLR) double mutant inhibitors are required. In this study, fragment-based QSAR models (GQSAR) were generated for pyridinylimidazole derivatives having biological activity against TMLR mutants. The GQSAR model developed using partial least squares regression via stepwise forward-backward variable selection technique showed best results as judged using statistical parameters (r2 , q2 , and pred_r2 ). Additionally, applicability domain of the model was verified using Williams plot, which indicated that the predicted data are reliable. The GQSAR provided site-specific clues wherein modifications related to decreasing lipophilic character and rotatable bonds and increasing SaaCHE-index are required for improving inhibitory activity. Overall, the study indicated that the presence of acrylamide at R5 is essential for covalent bond formation with Cys797 and occurrence of aromatic residue at R2 is required for occupying hydrophobic region next to Met790 gatekeeper residue. Based on this informa...Continue Reading

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May 29, 2018·Chemical Biology & Drug Design·Shehnaz FatimaSubhash Mohan Agarwal

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Citations

Sep 21, 2019·Journal of Receptor and Signal Transduction Research·Shehnaz Fatima, Subhash Mohan Agarwal
Oct 16, 2020·Chemical Biology & Drug Design·Ravi SainiSubhash Mohan Agarwal

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