QSAR study of flavonoid derivatives as p56lck tyrosinkinase inhibitors

Bioorganic & Medicinal Chemistry
Abhilash ThakurMamta Thakur

Abstract

QSAR studies on 104 flavonoid derivatives as p56lck protein tyrosine kinase inhibitors were performed using hydration energy and logP as predictor parameters. The results obtained demonstrate in detail, which specify that hydration energy and hydrophobic parameters of the compounds play a significant role in developing QSAR models. The significance of presence and absence of substituents on particular position is successfully explored with the help of indicator parameters. The results are critically discussed on the basis of multiple linear regression parameters.

References

May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K M AbrahamR M Perlmutter
Jan 25, 1991·Cell·L C CantleyS Soltoff
Feb 1, 1991·Journal of Medicinal Chemistry·M CushmanR L Geahlen
Apr 20, 1990·Cell·A Ullrich, J Schlessinger
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J B BolenN Rosen
Feb 1, 1989·The Journal of Antibiotics·H OgawaraY Seoda
Dec 1, 1989·Current Opinion in Cell Biology·T Hunter
Sep 1, 1989·Journal of Natural Products·R L GeahlenD E Pratt
Jan 1, 1983·Annual Review of Biochemistry·J M Bishop
Jan 1, 1996·Progress in Medicinal Chemistry·P W GroundwaterM A Munawar

❮ Previous
Next ❯

Citations

Mar 28, 2009·International Journal of Molecular Sciences·Afshin Fassihi, Razieh Sabet
May 20, 2006·Medicinal Research Reviews·P FrescoM P M Marques
Jun 16, 2009·Journal of Biochemical and Molecular Toxicology·Abhilash Thakur, Mamta Thakur
Mar 10, 2009·Journal of Chemical Information and Modeling·Chin Y LiewChun W Yap
Jan 24, 2006·Journal of Chemical Information and Modeling·Mamta ThakurKrishnan Balasubramanian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Bioorganic & Medicinal Chemistry
Andrzej Bak, Jaroslaw Polanski
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Carolina JullianClaudio Olea-Azar
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Carolina JullianClaudio Olea-Azar
© 2021 Meta ULC. All rights reserved