QSAR study of flavonoid derivatives as p56lck tyrosinkinase inhibitors

Bioorganic & Medicinal Chemistry
Abhilash ThakurMamta Thakur


QSAR studies on 104 flavonoid derivatives as p56lck protein tyrosine kinase inhibitors were performed using hydration energy and logP as predictor parameters. The results obtained demonstrate in detail, which specify that hydration energy and hydrophobic parameters of the compounds play a significant role in developing QSAR models. The significance of presence and absence of substituents on particular position is successfully explored with the help of indicator parameters. The results are critically discussed on the basis of multiple linear regression parameters.


May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K M AbrahamR M Perlmutter
Jan 25, 1991·Cell·L C CantleyS Soltoff
Feb 1, 1991·Journal of Medicinal Chemistry·M CushmanR L Geahlen
Apr 20, 1990·Cell·A Ullrich, J Schlessinger
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J B BolenN Rosen
Feb 1, 1989·The Journal of Antibiotics·H OgawaraY Seoda
Dec 1, 1989·Current Opinion in Cell Biology·T Hunter
Sep 1, 1989·Journal of Natural Products·R L GeahlenD E Pratt
Jan 1, 1983·Annual Review of Biochemistry·J M Bishop
Jan 1, 1996·Progress in Medicinal Chemistry·P W GroundwaterM A Munawar

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