Abstract
The QT interval is a risk marker for cardiac events such as torsades de pointes. However, QT measurements obtained from a 12-lead ECG during clinic hours may not capture the full extent of a patient's daily QT range. The purpose of this study was to evaluate the utility of 24-hour Holter ECG recording in patients with long QT syndrome (LQTS) to identify dynamic changes in the heart rate-corrected QT interval and to investigate methods of visualizing the resulting datasets. Beat-to-beat QTc (Bazett) intervals were automatically measured across 24-hour Holter recordings from 202 LQTS type 1, 89 type 2, and 14 type 3 genotyped patients and a reference group of 200 healthy individuals. We measured the percentage of beats with QTc greater than the gender-specific threshold (QTc ≥470 ms in women and QTc ≥450 ms in men). The percentage of beats with QTc prolongation was determined across the 24-hour recordings. Based on the median percentage of heartbeats per patient with QTc prolongation, LQTS type 1 patients showed more frequent QTc prolongation during the day (~3 PM) than they did at night (~3 AM): 97% vs 48%, P ~10(-4) for men, and 68% vs 30%, P ~10(-5) for women. LQTS type 2 patients showed less frequent QTc prolongation during t...Continue Reading
References
Jan 4, 2001·Circulation·P J SchwartzR Bloise
Jun 19, 2002·European Heart Journal·T NodaW Shimizu
Nov 21, 2009·Journal of the American College of Cardiology·Wataru ShimizuScott McNitt
May 18, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Fabrice ExtramianaAntoine Leenhardt
Dec 28, 2010·Journal of the American College of Cardiology·Ilan GoldenbergLi Zhang
Mar 29, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Dimitry MigdalovichIlan Goldenberg
Oct 2, 2012·Journal of Electrocardiology·Jean-Philippe Couderc
Jul 25, 2013·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Fabrice ExtramianaAntoine Leenhardt
Nov 12, 2013·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Alon BarsheshetIlan Goldenberg
Citations
Jan 27, 2016·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Ovunc KocabasMehmet K Aktas
Nov 21, 2017·Journal of Forensic Sciences·Richard M LuceriHenry Halperin
Jun 29, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Masao YoshinagaHiromitsu Ogata
Jun 29, 2018·Journal of Arrhythmia·Aki SaitoMasao Yoshinaga
Mar 27, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Yoshiharu OgawaSachiko Kido
Aug 24, 2019·Pediatric Cardiology·Eimear WallaceTerence Prendiville
Oct 7, 2017·Current Opinion in Cardiology·Christian Steinberg
Aug 12, 2016·Physiological Measurement·S A ImmanuelJ I Vandenberg
Aug 14, 2020·Oral Diseases·Daniela AdamoMichele Mignogna
Apr 12, 2016·The Journal of Physiology·Adam P HillJamie I Vandenberg
Aug 3, 2017·The Medical Journal of Australia·Kathryn Waddell-SmithJonathan R Skinner
Aug 28, 2018·Current Treatment Options in Cardiovascular Medicine·Nikhil Ahluwalia, Hariharan Raju
Dec 9, 2017·Pacing and Clinical Electrophysiology : PACE·Christopher W FollansbeeGaurav Arora
Jan 28, 2020·Heart, Lung & Circulation·Kathryn E Waddell-SmithJonathan R Skinner
Feb 26, 2021·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Hanna LenhoffMats Frick
Jul 11, 2021·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Kenji YodogawaWataru Shimizu