"QT clock" to improve detection of QT prolongation in long QT syndrome patients

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Alex PageJean-Philippe Couderc

Abstract

The QT interval is a risk marker for cardiac events such as torsades de pointes. However, QT measurements obtained from a 12-lead ECG during clinic hours may not capture the full extent of a patient's daily QT range. The purpose of this study was to evaluate the utility of 24-hour Holter ECG recording in patients with long QT syndrome (LQTS) to identify dynamic changes in the heart rate-corrected QT interval and to investigate methods of visualizing the resulting datasets. Beat-to-beat QTc (Bazett) intervals were automatically measured across 24-hour Holter recordings from 202 LQTS type 1, 89 type 2, and 14 type 3 genotyped patients and a reference group of 200 healthy individuals. We measured the percentage of beats with QTc greater than the gender-specific threshold (QTc ≥470 ms in women and QTc ≥450 ms in men). The percentage of beats with QTc prolongation was determined across the 24-hour recordings. Based on the median percentage of heartbeats per patient with QTc prolongation, LQTS type 1 patients showed more frequent QTc prolongation during the day (~3 PM) than they did at night (~3 AM): 97% vs 48%, P ~10(-4) for men, and 68% vs 30%, P ~10(-5) for women. LQTS type 2 patients showed less frequent QTc prolongation during t...Continue Reading

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Citations

Jan 27, 2016·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Ovunc KocabasMehmet K Aktas
Jun 29, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Masao YoshinagaHiromitsu Ogata
Mar 27, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Yoshiharu OgawaSachiko Kido
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Jan 28, 2020·Heart, Lung & Circulation·Kathryn E Waddell-SmithJonathan R Skinner
Feb 26, 2021·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Hanna LenhoffMats Frick
Jul 11, 2021·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Kenji YodogawaWataru Shimizu

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