QT instability, an indicator of augmented arrhythmogenesis, increases with the progression of myxomatous mitral valve disease in dogs

Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology
B C BrülerM G Sousa

Abstract

To investigate QT instability in dogs with myxomatous mitral valve disease (MMVD) and to determine if this is associated with arrhythmogenesis. One hundred sixty-seven MMVD dogs that met the study criteria were included. Echocardiographic and electrocardiographic data were gathered. Fifty consecutive QT intervals were recorded for each dog. Both heart rate-corrected and uncorrected QT intervals were used to calculate average QT (QTa), QT variance (QTv), total instability (TI), short-term instability (STI), and long-term instability (LTI). Sensitivity and specificity of QTa, QTv, TI, STI, and LTI in identifying arrhythmias and cardiac remodeling were calculated. Patient follow-ups were obtained for analyses of disease progression and survival. An increase related to progression was documented for all the studied indices. QTa and STI best identified dilated hearts and arrhythmias, respectively. Dogs with QTa >272 ms and STI >8 ms were 15% more likely to develop ventricular arrhythmias (likelihood ratios of 2.31 [P = 0.0008] and 2.09 [P = 0.0049], respectively). A QTa >258 ms discriminated American College of Veterinary Internal Medicine stage B1 from stages B2/C disease with a sensitivity of 63% and specificity of 61%. Dogs in Am...Continue Reading

Citations

Apr 4, 2021·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·B C P VilaM G Sousa
Jul 10, 2021·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·G Romito, M Cipone

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