PMID: 9535496Apr 16, 1998Paper

QT interval dispersion: dispersion of ventricular repolarization or dispersion of QT interval?

Journal of Electrocardiology
R L LuxB Taccardi

Abstract

The QT interval (QTI) has long been useful as a clinical index of the duration of ventricular repolarization, particularly as a marker of prolonged repolarization and its well-established association with arrhythmogenic cardiac states. Likewise, inhomogeneity (dispersion) of repolarization has been linked definitively to increased susceptibility to reentrant arrhythmias. Recent studies have reported the use of QTI dispersion as a meaningful clinical index to identify patients at risk, but the interpretation of the measurement has been controversial. A Langendorff-perfused, isolated canine heart suspended in a torso-shaped, electrolytic tank filled with NaCl-sucrose solution was used to investigate the relationship between body surface QTIs and ventricular repolarization measured directly from the cardiac surface by using activation-recovery intervals, which have been documented to reflect the duration of local action potentials as well as local refractory periods. The data showed poor correlation between cardiac surface activation-recovery intervals and QTIs, as well as the insensitivity of QTIs to regional repolarization shortening in the presence of prolonged repolarization elsewhere. Furthermore, the data confirmed that tors...Continue Reading

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Citations

Oct 19, 2004·Basic Research in Cardiology·Frederik VossWolfgang Schoels
Sep 1, 2004·International Journal of Cardiology·Giuseppe BarlettaAntonio Michelucci
Aug 29, 2000·The American Journal of Cardiology·P M Rautaharju
Oct 31, 2000·The American Journal of Cardiology·P M Rautaharju
Aug 19, 2007·Expert Opinion on Drug Metabolism & Toxicology·Thomas MeyerElke Guenther
Jan 15, 2000·Journal of Cardiovascular Electrophysiology·B B PunskeB Taccardi
Apr 21, 2004·Pancreas·Junichi SakagamiTakeshi Okanoue
Sep 20, 2011·Journal of Electrocardiology·Robert L Lux, Leonard S Gettes
Jun 11, 2005·Journal of Cardiovascular Electrophysiology·Robert L Lux, Mohamed H Hamdan
Nov 7, 2013·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Małgorzata FereniecRoman Maniewski

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