QT interval variability in panic disorder patients after isoproterenol infusions

The International Journal of Neuropsychopharmacology
R Pohl, V K Yeragani

Abstract

Anxiety symptoms are associated with a marked increase in sudden cardiac death, suggesting an abnormality in the autonomic control of the heart. We examined the effects of sympathetic stimulation on QT interval variability in panic disorder patients by infusing the ss-adrenergic agonist isoproterenol in 6 panic disorder patients and 11 normal subjects. The ECG signal was analysed before the infusion and after 5 min after the infusion was started. The outcome measures were the QT variability normalized for mean QT interval (QTvm) and the QT variability index (QTvi), a measure of QT variability normalized by the concomitant heart rate variability. Patients with panic disorder had more variability in QT interval duration than normal controls and this variability was increased further by sympathetic stimulation with isoproterenol. The isoproterenol-associated increase in QT interval occurred in controls in the absence of significant anxiety. However, on one of two measures, the increase in QT interval variability was greater in patients with panic disorder, suggesting a greater sensitivity to isoproterenol or to isoproterenol-induced anxiety.

Citations

Aug 23, 2003·Journal of Psychosomatic Research·Robert PohlVikram Yeragani
Oct 31, 2012·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Andre PittigMichelle G Craske
Jul 4, 2006·Journal of Psychosomatic Research·Vikram Kumar YeraganiNagaraj Desai
Jan 30, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Mathias BaumertPaul G A Volders
Apr 16, 2015·Systematic Reviews·Phillip J TullyHarald Baumeister
Nov 28, 2016·Applied Psychophysiology and Biofeedback·Katja PetrowskiMartin Siepmann
Jul 5, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Mathias BaumertEugene Nalivaiko
Nov 21, 2002·Heart Disease·Vikram Kumar YeraganiNagaraj Desai
Nov 1, 2016·Current Cardiology Reports·Phillip J TullySuzanne Cosh
Nov 30, 2004·Clinical and Experimental Pharmacology & Physiology·Emily R NolanVikram Kumar Yeragani

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