Abstract
Organophosphates (OP) are used extensively as pesticides and as chemical weapons. Cardiotoxicity is a major concern in survivors of the acute poisoning. To characterize the delayed cardiac effects of OP, rats were poisoned by intraperitoneal administration of dichlorvos. In group I, poisoning (0.25-, 0.75-, 1.4-LD50) was followed by application of atropine and obidoxime. In group II, poisoning (0.35-, 0.5-LD50) was done without antidotes. Cardiac evaluation included electrocardiography and echocardiography 2- and 6-week post-exposure, arrhythmia susceptibility following administration of Isoproterenol (150 mcg/kg), and histological evaluation. All poisoned animals displayed cholinergic symptoms. In group I, all animals exposed to 1.4-LD50 (n = 3) had profound convulsions and died despite antidote treatment. However, in the lower doses, all animals survived and no cardiac abnormalities were noted during follow-up. In group II, six animals had convulsions and died. Surviving animals had mild but significant prolongation of corrected QT at both 2 and 6 weeks, compared to shams. There were no notable echocardiographic, gravimetric, or histological differences between poisoned and sham animals. Our data indicate that dichlorvos pois...Continue Reading
References
Jun 1, 1992·Pharmacology & Toxicology·S A Ben-HaimY Edoute
Jul 27, 1991·Lancet·L RosenstockK Claypoole
Sep 15, 1991·Toxicology and Applied Pharmacology·H Ben-AmiU Taitelman
Jun 1, 1987·Toxicology Letters·P Robineau, P Guittin
May 1, 1982·The American Journal of Cardiology·A LudomirskyE Kaplinsky
Feb 1, 1993·Chest·A RothJ Atsmon
Aug 1, 1996·Annals of Emergency Medicine·T OkumuraS Hinohara
Sep 1, 1996·The American Journal of Emergency Medicine·F R ChuangK T Hsu
Dec 11, 2003·Current Treatment Options in Neurology·Christopher P. Holstege, Alexander B. Baer
Jul 22, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·N AllonE Grauer
Sep 12, 2006·Cell Biology and Toxicology·O AkturkI Altuntas
Oct 31, 2006·Echocardiography·Alexander GhanemKlaus Tiemann
May 17, 2007·International Journal of Clinical Practice·A BaydinT Yardan
Aug 21, 2007·Lancet·Michael EddlestonAndrew H Dawson
Jul 29, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Yoram EtzionAmos Katz
Mar 10, 2009·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·S AnandDalbir Singh
Apr 18, 2009·The American Journal of Emergency Medicine·Ataman KoseAbdullah T Demiryurek
Jun 18, 2010·European Journal of Pharmacology·Jana Kmecova, Jan Klimas
Feb 22, 2011·Cardiovascular Toxicology·Subash VijayakumarK Mohan Rao
Jan 28, 2012·Journal of Forensic and Legal Medicine·Edibe Karasu-MinareciGul Ozbey
May 3, 2012·Journal of Cardiovascular Pharmacology·Swapnil V ShewaleMariana Morris
May 7, 2014·Annals of Internal Medicine·Yossi RosmanMichael Kassirer
Jun 3, 2014·Toxicology·Shai ShrotYoel Yaari
Jun 11, 2014·PloS One·Michal MorNoah Liel-Cohen
Aug 15, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Y S ChaS O Hwang
Apr 29, 2015·Neurotoxicology·Shai ShrotYoram Cohen
Jun 9, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Asif MachhadaAlexander V Gourine
Jun 13, 2015·Circulation. Arrhythmia and Electrophysiology·Michael BietRobert Dumaine
Jun 1, 2005·Journal of Medical Ultrasonics·UNKNOWN Terminology and Diagnostic Criteria Committee of The Japan Society of Ultrasonics in Medicine