PMID: 8593946Mar 1, 1996Paper

QTc duration is associated with levels of insulin and glucose intolerance. The Zutphen Elderly Study

Diabetes
J M DekkerD Kromhout

Abstract

Prolongation of heart rate-adjusted QT length (corrected QT interval [QTc]) is associated with elevated risk of coronary heart disease and sudden death. This may have to do with autonomic cardiac control. Because insulin is known to stimulate sympathetic activity, we studied the association of insulin level and glucose tolerance with QTc. In 1990, 383 elderly men 70-89 years of age without previous myocardial infarctions or known diabetes had a 12-lead electrocardiogram recorded and glucose tolerance determined in the frame of an ongoing follow-up study. QTc was significantly associated with fasting glucose, insulin, and C-peptide and glucose levels 60 and 120 min after an oral glucose load. For fasting C-peptide and the area under the glucose curve (AUGC), this association could not be explained by the concomitant occurrence of other risk factors of coronary heart disease. Furthermore, fasting C-peptide and the AUGC were independently additive predictors of QTc duration. The difference in QTc between men in the extreme quintiles of both variables was 22 ms. QTc prolongation seems to be part of the insulin resistance syndrome. The association may be explained by increased sympathetic activity induced by high insulin levels. An ...Continue Reading

Citations

Oct 12, 2000·Diabetes/metabolism Research and Reviews·K SugimotoA A Sima
Aug 21, 2002·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·Radu NegoesAlin Achim
May 30, 2002·Life Sciences·Martina C M Ryan, Jogin H Thakore
Dec 21, 2000·International Journal of Cardiology·G T KoC S Cockram
May 21, 2005·Journal of Human Hypertension·G LeottaF Veglio
Apr 12, 2003·Pacing and Clinical Electrophysiology : PACE·Akihiko NogamiKazutaka Aonuma
Nov 18, 2006·Diabetes Technology & Therapeutics·C Leigh Broadhurst, Philip Domenico
Jul 19, 2011·QJM : Monthly Journal of the Association of Physicians·E OikonomouC Stefanadis
Dec 25, 2007·Exercise and Sport Sciences Reviews·Mercedes R Carnethon, Lynette L Craft
Feb 3, 2005·Pacing and Clinical Electrophysiology : PACE·Bojan VrtovecTodd T Schlegel
Jan 16, 2013·Experimental Diabetes Research·Xiang LiJian-qin Liu
Mar 29, 2006·Diabetes Care·Mercedes R CarnethonUNKNOWN Diabetes Prevention Program Research Group
Aug 13, 2009·Journal of Atherosclerosis and Thrombosis·Ryoma MichishitaToshiyuki Tsuruta
Mar 7, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Giovanni TargherChristopher D Byrne
Dec 14, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bertrand CaillierBenoit Drolet
Dec 8, 2009·Autonomic Neuroscience : Basic & Clinical·Alessandra FiorentiniLuigi Tubani
Nov 3, 2009·Atherosclerosis·Nan Hee KimWilliam C Knowler
Jun 9, 2015·Journal of Nutritional Science and Vitaminology·Ryoma MichishitaUNKNOWN Nakagawa Study Group
Mar 21, 2007·International Journal of Cardiology·A Perciaccante, A Fiorentini
Oct 31, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·G AndrássyA Szabo
Jan 18, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·D GordinP-H Groop
Dec 17, 2009·Clinical Cardiology·Weiju LiRutai Hui
May 4, 2010·The Journal of Clinical Hypertension·Andrew GrandinettiPhillip Low
Jan 12, 2005·Clinical Biochemistry·Andrew GrandinettiAndré G Theriault
Aug 30, 2012·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Ahsan H KhandokerHerbert F Jelinek
Feb 22, 2005·International Journal of Cardiology·Gianluca IacobellisFrida Leonetti
Nov 15, 2000·The American Journal of Cardiology·A NomuraA J Moss
Jun 14, 2006·Autonomic Neuroscience : Basic & Clinical·Andrew GrandinettiPhillip A Low
Apr 4, 2006·Journal of Electrocardiology·Charles NordinPaul Marantz
Jul 2, 2005·American Heart Journal·Matjaz VrtovecBranislav Radovancevic
Mar 11, 2009·Pacing and Clinical Electrophysiology : PACE·Bojan VrtovecFrancois Haddad
Sep 23, 2014·Geriatrics & Gerontology International·Ryoma MichishitaUNKNOWN Nakagawa Study Group
Jul 12, 2005·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Prakash SeshadriNayyar Iqbal
Nov 12, 2015·Journal of Cardiovascular Medicine·Alessandro GalluzzoFiorenzo Gaita
Mar 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Hun-Sub ShinJung-Ro Park
Oct 31, 2006·European Journal of Epidemiology·Eunhee KimChol Shin
Aug 2, 2003·Stroke; a Journal of Cerebral Circulation·Claudia R L CardosoWaldemar Deccache
May 8, 2004·Journal of Endocrinological Investigation·M VeglioP Cavallo-Perin
Aug 16, 2000·Scandinavian Journal of Clinical and Laboratory Investigation·P K ChristensenH H Parving
Nov 10, 2000·Aging : Clinical and Experimental Research·R Marfella, D Giugliano
Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A GastaldelliE Ferrannini

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