Abstract
The study concerns the relationship of the corrected QT (QTc) interval to 6.4 years of survival and to measures of cardiac function, such as echocardiographic variables and plasma levels of brain natriuretic peptide (BNP), in 75-year-old people. QTc was measured in a 12-lead electrocardiogram (ECG) in 210 men and 223 women, comprising a randomly selected sample from the general population (70% participation rate). The Sicard 440/740 computer-analysis program, with Hodges' formula for heart rate-based QT correction, was used. The optimal cut-off point for predicting survival according to the receiver operating characteristic curve was found between 429 and 430 ms. Individuals with a QTc interval of > or =430 ms (n = 115) had decreased survival when compared with those with shorter QTc interval (n = 318); the relative risk was 2.4 (95% confidence interval 1.5-3.7). The predictive ability of QTc reflects an association between QTc and the following variables: BNP, left ventricular mass, and left ventricular ejection fraction (but not diastolic filling patterns). Both Hodges' and Bazett's formulae for heart rate correction of the QT interval were useful for predicting survival. The median QTc was 415 ms using Hodges' formula and 43...Continue Reading
References
Dec 19, 1991·The New England Journal of Medicine·J L WillemsG van Herpen
Jan 1, 1991·The American Journal of Cardiology·R J GoldbergD Levy
Jan 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·D J Ewing, J M Neilson
Jan 1, 1994·Journal of Electrocardiology·P W MacfarlaneT F Yang
Aug 1, 1994·Circulation·J M DekkerD Kromhout
May 15, 1994·The American Journal of Cardiology·P M RautaharjuC D Furberg
Jan 1, 1996·Journal of the American College of Cardiology·J MolnarJ E Rosenthal
Jun 1, 1996·The American Journal of Cardiology·G J FahyK Robinson
Dec 1, 1996·Clinical Cardiology·M Reardon, M Malik
Mar 15, 1997·The American Journal of Cardiology·J BankerJ Reiffel
Apr 1, 1999·European Heart Journal·M C de BruyneD E Grobbee
Aug 6, 1999·Stroke; a Journal of Cerebral Circulation·A FestaS M Haffner
Aug 24, 1999·International Journal of Cardiology·W ShamimA J Coats
Sep 14, 1999·Journal of the American College of Cardiology·M S LauerE J Topol
Jun 1, 2000·Indian Journal of Pediatrics·R H Fletcher
Apr 5, 2001·European Heart Journal·P HedbergI Ringqvist
Feb 16, 2002·Heart·M MalikA J Camm
Jul 12, 2002·Statistics in Medicine·Antonio Ciampi, Fulin Zhang
Apr 1, 2003·Circulation·Bojan VrtovecBranislav Radovancevic
Jun 1, 1960·Circulation·H BLACKBURNS PUNSAR
Oct 1, 2003·Circulation·Richard S CrowAaron R Folsom
Feb 21, 2004·Journal of the American College of Cardiology·Jacqueline M DekkerUNKNOWN ARIC Study
Feb 21, 2004·Journal of the American College of Cardiology·Peter M Okin
May 12, 2004·Archives of Internal Medicine·Alicia MontanezCharles H Hennekens
May 27, 2004·Diabetes·Stuart P LeeSimon R Heller
Sep 25, 2004·American Heart Journal·Pär HedbergIvar Ringqvist
Citations
Oct 26, 2011·Archives of Internal Medicine·Yiyi ZhangEliseo Guallar
Nov 3, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·John A ChiladakisDimitrios Alexopoulos
Jun 29, 2011·Epidemiology·Yiyi ZhangEliseo Guallar
Mar 10, 2011·PloS One·Yiyi ZhangEliseo Guallar
Apr 25, 2009·Journal of Hypertension·Gil F SallesElizabeth S Muxfeldt
Dec 23, 2009·Asian Cardiovascular & Thoracic Annals·Mahnoosh ForoughiSeyed-Ahmad Hassantash
Jul 16, 2016·PloS One·Berihun GebremedhinLaura S Epp