QTL detection power of multi-parental RIL populations in Arabidopsis thaliana.

Heredity
J R KlasenBenjamin Stich

Abstract

A major goal of today's biology is to understand the genetic basis of quantitative traits. This can be achieved by statistical methods that evaluate the association between molecular marker variation and phenotypic variation in different types of mapping populations. The objective of this work was to evaluate the statistical power of quantitative trait loci (QTL) detection of various multi-parental mating designs, as well as to assess the reasons for the observed differences. Our study was based on an empirical data of 20 Arabidopsis thaliana accessions, which have been selected to capture the maximum genetic diversity. The examined mating designs differed strongly with respect to the statistical power to detect QTL. We observed the highest power to detect QTL for the diallel cross with random mating design. The results of our study suggested that performing sibling mating within subpopulations of joint-linkage mapping populations has the potential to considerably increase the power for QTL detection. Our results, however, revealed that using designs in which more than two parental alleles segregate in each subpopulation increases the power even more.

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References

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Citations

Aug 2, 2013·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·N A AlimiF A van Eeuwijk
Nov 15, 2015·Plant Science : an International Journal of Experimental Plant Biology·Laura PascualMathilde Causse
Apr 10, 2015·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·B Emma HuangColin R Cavanagh
Mar 4, 2017·Molecular Plant·Qin YangMingliang Xu
Mar 28, 2019·G3 : Genes - Genomes - Genetics·Gregory R KeeleWilliam Valdar
Apr 22, 2014·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Katherine J LinsellKlaus H Oldach
Apr 8, 2018·G3 : Genes - Genomes - Genetics·Rachel F BegheynBruno Studer
Oct 19, 2019·BMC Plant Biology·José Cruz Jiménez-GalindoBernardo Ordás

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